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Caffeine as a Tool to Explore Active Cognitive Processing Stages in Two-Choice Tasks.

Journal Article


Abstract


  • Background: We used caffeine as a tool to explore the active cognitive-processing stages in a simple Go/NoGo task, in terms of the event-related potential (ERP) components elicited by the Go and NoGo stimuli. Methods: Two hundred and fifty milligrams of caffeine was administered to adult participants (N = 24) in a randomized double-blind placebo-controlled repeated-measures crossover study. Two blocks of an equiprobable auditory Go/NoGo task were completed, each with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz, all 60 dB sound pressure level (SPL). Results: Major ERP effects of caffeine were apparent in enhancements of the Go N1-1, P3b, and Slow Wave (SW), and the NoGo Processing Negativity, SW, and NoGo Late Positivity. Conclusions: Novel differential findings indicate the potential of our caffeine as a tool approach to elucidate the functional nature of ERP markers of active cognitive processing in a range of developmental and clinical populations.

Publication Date


  • 2020

Citation


  • Barry, R. J., Fogarty, J. S., & De Blasio, F. M. (2020). Caffeine as a Tool to Explore Active Cognitive Processing Stages in Two-Choice Tasks.. Journal of caffeine and adenosine research, 10(2), 71-83. doi:10.1089/caff.2019.0021

Web Of Science Accession Number


Start Page


  • 71

End Page


  • 83

Volume


  • 10

Issue


  • 2

Abstract


  • Background: We used caffeine as a tool to explore the active cognitive-processing stages in a simple Go/NoGo task, in terms of the event-related potential (ERP) components elicited by the Go and NoGo stimuli. Methods: Two hundred and fifty milligrams of caffeine was administered to adult participants (N = 24) in a randomized double-blind placebo-controlled repeated-measures crossover study. Two blocks of an equiprobable auditory Go/NoGo task were completed, each with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz, all 60 dB sound pressure level (SPL). Results: Major ERP effects of caffeine were apparent in enhancements of the Go N1-1, P3b, and Slow Wave (SW), and the NoGo Processing Negativity, SW, and NoGo Late Positivity. Conclusions: Novel differential findings indicate the potential of our caffeine as a tool approach to elucidate the functional nature of ERP markers of active cognitive processing in a range of developmental and clinical populations.

Publication Date


  • 2020

Citation


  • Barry, R. J., Fogarty, J. S., & De Blasio, F. M. (2020). Caffeine as a Tool to Explore Active Cognitive Processing Stages in Two-Choice Tasks.. Journal of caffeine and adenosine research, 10(2), 71-83. doi:10.1089/caff.2019.0021

Web Of Science Accession Number


Start Page


  • 71

End Page


  • 83

Volume


  • 10

Issue


  • 2