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EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

Journal Article


Abstract


  • Members of the Eph family of tyrosine kinase receptors have been implicated in the regulation of developmental processes and, in particular, axon guidance in the developing nervous system. The function of the EphA4 (Sek1) receptor was explored through creation of a null mutant mouse. Mice with a null mutation in the EphA4 gene are viable and fertile but have a gross motor dysfunction, which is evidenced by a loss of coordination of limb movement and a resultant hopping, kangaroo-like gait. Consistent with the observed phenotype, anatomical studies and auterograde tracing experiments reveal major disruptions o[the corticospinal tract within the medulla and spinal cord in the null mutant animals. These results demonstrate a critical role for EphA4 in establishing the corticospinal projection.

Publication Date


  • 1998

Citation


  • Dottori, M., Hartley, L., Galea, M., Paxinos, G., Polizzotto, M., Kilpatrick, T., . . . Boyd, A. W. (1998). EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proceedings of the National Academy of Sciences of the United States of America, 95(22), 13248-13253. doi:10.1073/pnas.95.22.13248

Scopus Eid


  • 2-s2.0-13144259630

Start Page


  • 13248

End Page


  • 13253

Volume


  • 95

Issue


  • 22

Abstract


  • Members of the Eph family of tyrosine kinase receptors have been implicated in the regulation of developmental processes and, in particular, axon guidance in the developing nervous system. The function of the EphA4 (Sek1) receptor was explored through creation of a null mutant mouse. Mice with a null mutation in the EphA4 gene are viable and fertile but have a gross motor dysfunction, which is evidenced by a loss of coordination of limb movement and a resultant hopping, kangaroo-like gait. Consistent with the observed phenotype, anatomical studies and auterograde tracing experiments reveal major disruptions o[the corticospinal tract within the medulla and spinal cord in the null mutant animals. These results demonstrate a critical role for EphA4 in establishing the corticospinal projection.

Publication Date


  • 1998

Citation


  • Dottori, M., Hartley, L., Galea, M., Paxinos, G., Polizzotto, M., Kilpatrick, T., . . . Boyd, A. W. (1998). EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proceedings of the National Academy of Sciences of the United States of America, 95(22), 13248-13253. doi:10.1073/pnas.95.22.13248

Scopus Eid


  • 2-s2.0-13144259630

Start Page


  • 13248

End Page


  • 13253

Volume


  • 95

Issue


  • 22