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Orientin improves depression-like behavior and BDNF in chronic stressed mice

Journal Article


Abstract


  • Scope

    Oxidative stress is involved in chronic stress-induced depression and the disruption of neurotransmission and neuroplasticity. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential antidepressant effects of orientin against chronic stress and its underlying mechanisms.

    Methods and results

    The chronic unpredictable mild stress (CUMS) model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 2 weeks of the CUMS protocol, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. Administration of orientin significantly alleviated the CUMS-induced depression-like behavior, including sucrose preference reduction, locomotor activity decline, and hypomotility. Orientin treatment attenuated the oxidative stress markers and increased the concentrations of serotonin and norepinephrine in the hippocampus and prefrontal cortex of CUMS mice. Orientin treatment also increased the brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) of CUMS mice.

    Conclusion

    Orientin exerts antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic stress-induced depression.

Authors


  •   Liu, Yi (external author)
  •   Lan, Nuo (external author)
  •   Ren, Jing (external author)
  •   Wu, Yizhen (external author)
  •   Wang, Shu-Ting (external author)
  •   Huang, Xu-Feng
  •   Yu, Yinghua

Publication Date


  • 2015

Citation


  • Liu, Y., Lan, N., Ren, J., Wu, Y., Wang, S., Huang, X. & Yu, Y. (2015). Orientin improves depression-like behavior and BDNF in chronic stressed mice. Molecular Nutrition and Food Research, 59 (6), 1130-1142.

Scopus Eid


  • 2-s2.0-84930178613

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/539

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 1130

End Page


  • 1142

Volume


  • 59

Issue


  • 6

Place Of Publication


  • Germany

Abstract


  • Scope

    Oxidative stress is involved in chronic stress-induced depression and the disruption of neurotransmission and neuroplasticity. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential antidepressant effects of orientin against chronic stress and its underlying mechanisms.

    Methods and results

    The chronic unpredictable mild stress (CUMS) model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 2 weeks of the CUMS protocol, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. Administration of orientin significantly alleviated the CUMS-induced depression-like behavior, including sucrose preference reduction, locomotor activity decline, and hypomotility. Orientin treatment attenuated the oxidative stress markers and increased the concentrations of serotonin and norepinephrine in the hippocampus and prefrontal cortex of CUMS mice. Orientin treatment also increased the brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) of CUMS mice.

    Conclusion

    Orientin exerts antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic stress-induced depression.

Authors


  •   Liu, Yi (external author)
  •   Lan, Nuo (external author)
  •   Ren, Jing (external author)
  •   Wu, Yizhen (external author)
  •   Wang, Shu-Ting (external author)
  •   Huang, Xu-Feng
  •   Yu, Yinghua

Publication Date


  • 2015

Citation


  • Liu, Y., Lan, N., Ren, J., Wu, Y., Wang, S., Huang, X. & Yu, Y. (2015). Orientin improves depression-like behavior and BDNF in chronic stressed mice. Molecular Nutrition and Food Research, 59 (6), 1130-1142.

Scopus Eid


  • 2-s2.0-84930178613

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/539

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 1130

End Page


  • 1142

Volume


  • 59

Issue


  • 6

Place Of Publication


  • Germany