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High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice

Journal Article


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Abstract


  • Background: Obesity has been found to be associated with colon cancer. However, the mechanism of this relationship is unclear and thus a good animal model is required. Our previous research showed that some mice developed diet-induced obesity (DIO) whilst others were diet-resistant (DR) when fed a high-fat diet.

    Methods: In the present study, we have tested the effects of a high-fat diet on the formation of colon polyps induced by azoxymethane (AOM) in both DIO and DR mice.

    Results: We found that the DIO mice have developed 2.5 times of polyps compared to the DR mice (P<0.05) and 3.4 times of polyps compared to the low fat fed mice (P<0.05). Although the DR mice tended to have more polyps than the low-fat diet fed mice, this was not statistically significant. The DIO mice could have an increased polyp formation due to obesity-related cancer risk factors and different gene expression from DR mice.

    Conclusions: DIO mice could be used as an appropriate model for studying obesity-associated colon cancer; however DR mice are not suitable because they don’t show any significant weight gains to indicate obesity.

    Keywords: Obesity-associated colon cancer; high-fat diet; diet-induced obesity (DIO); diet resistant (DR); polyp; animal model

Publication Date


  • 2015

Citation


  • Chen, J. & Huang, X. (2015). High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice. Annals of Translational Medicine, 3 (6), 79-1-79-4.

Scopus Eid


  • 2-s2.0-85015458469

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1587&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/565

Has Global Citation Frequency


Start Page


  • 79-1

End Page


  • 79-4

Volume


  • 3

Issue


  • 6

Place Of Publication


  • Hong Kong

Abstract


  • Background: Obesity has been found to be associated with colon cancer. However, the mechanism of this relationship is unclear and thus a good animal model is required. Our previous research showed that some mice developed diet-induced obesity (DIO) whilst others were diet-resistant (DR) when fed a high-fat diet.

    Methods: In the present study, we have tested the effects of a high-fat diet on the formation of colon polyps induced by azoxymethane (AOM) in both DIO and DR mice.

    Results: We found that the DIO mice have developed 2.5 times of polyps compared to the DR mice (P<0.05) and 3.4 times of polyps compared to the low fat fed mice (P<0.05). Although the DR mice tended to have more polyps than the low-fat diet fed mice, this was not statistically significant. The DIO mice could have an increased polyp formation due to obesity-related cancer risk factors and different gene expression from DR mice.

    Conclusions: DIO mice could be used as an appropriate model for studying obesity-associated colon cancer; however DR mice are not suitable because they don’t show any significant weight gains to indicate obesity.

    Keywords: Obesity-associated colon cancer; high-fat diet; diet-induced obesity (DIO); diet resistant (DR); polyp; animal model

Publication Date


  • 2015

Citation


  • Chen, J. & Huang, X. (2015). High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice. Annals of Translational Medicine, 3 (6), 79-1-79-4.

Scopus Eid


  • 2-s2.0-85015458469

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1587&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/565

Has Global Citation Frequency


Start Page


  • 79-1

End Page


  • 79-4

Volume


  • 3

Issue


  • 6

Place Of Publication


  • Hong Kong