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An antioxidant-like action for non-peroxidisable phospholipids using ferrous iron as a peroxidation initiator

Journal Article


Abstract


  • The degradation of phospholipids containing polyunsaturated fatty acids, termed peroxidation, poses a constant challenge to membranes lipid composition and function. Phospholipids with saturated (e.g. PC 16:0/16:0) and monounsaturated fatty acids (e.g. PC 16:0/18:1) are some of the most common phospholipids found in membranes and are generally not peroxidisable. The present experiments show that these non-peroxidisable phospholipids, when present in liposomes with peroxidisable phospholipids (i.e. those containing polyunsaturated fatty acids) such as PC 16:0/18:2 and Soy PC, produce an inhibitory effect on rates of peroxidation induced by ferrous-iron. This inhibitory effect acts to extend the duration of the lag phase by several-fold. If present in natural systems, this action could enhance the capacity of conventional antioxidant mechanisms in membranes. The results of this preliminary work suggest that non-peroxidisable phospholipids may exert an antioxidant-like action in membranes.

Publication Date


  • 2015

Citation


  • Cortie, C. H. & Else, P. L. (2015). An antioxidant-like action for non-peroxidisable phospholipids using ferrous iron as a peroxidation initiator. BBA: Biomembranes, 1848 (6), 1303-1307.

Scopus Eid


  • 2-s2.0-84925064432

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2912

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 1303

End Page


  • 1307

Volume


  • 1848

Issue


  • 6

Place Of Publication


  • Netherlands

Abstract


  • The degradation of phospholipids containing polyunsaturated fatty acids, termed peroxidation, poses a constant challenge to membranes lipid composition and function. Phospholipids with saturated (e.g. PC 16:0/16:0) and monounsaturated fatty acids (e.g. PC 16:0/18:1) are some of the most common phospholipids found in membranes and are generally not peroxidisable. The present experiments show that these non-peroxidisable phospholipids, when present in liposomes with peroxidisable phospholipids (i.e. those containing polyunsaturated fatty acids) such as PC 16:0/18:2 and Soy PC, produce an inhibitory effect on rates of peroxidation induced by ferrous-iron. This inhibitory effect acts to extend the duration of the lag phase by several-fold. If present in natural systems, this action could enhance the capacity of conventional antioxidant mechanisms in membranes. The results of this preliminary work suggest that non-peroxidisable phospholipids may exert an antioxidant-like action in membranes.

Publication Date


  • 2015

Citation


  • Cortie, C. H. & Else, P. L. (2015). An antioxidant-like action for non-peroxidisable phospholipids using ferrous iron as a peroxidation initiator. BBA: Biomembranes, 1848 (6), 1303-1307.

Scopus Eid


  • 2-s2.0-84925064432

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2912

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 1303

End Page


  • 1307

Volume


  • 1848

Issue


  • 6

Place Of Publication


  • Netherlands