Electro-stimulated release from a reduced graphene oxide composite hydrogel

Journal Article


Abstract


  • Electro-stimulated release was established using a novel, electro-conductive hydrogel system comprising Jeffamine polyetheramine and polyethylene glycol diglycidyl ether (PEGDGE) that was composited with reduced graphene oxide (rGO). The swelling response, morphology, mechanical and electrochemical properties of the composite hydrogel were investigated. Enhanced mechanical and electrical properties were observed with increased rGO content. Passive and electro-stimulated release of methyl orange (MO) from these gels was examined. A significant reduction in passive release of the dye was observed by incorporating rGO. Upon electrical stimulation, the release rate and dosage could be tuned through variation of the % w/w rGO, as well as the polarity and amplitude of the applied electric potential. A high level of control and flexibility was achieved demonstrating the applicability of this system for localised drug delivery applications.

Authors


  •   Kenna, Nicky Mac (external author)
  •   Calvert, Paul D. (external author)
  •   Morrin, Aoife (external author)
  •   Wallace, Gordon G.
  •   Moulton, Simon E. (external author)

Publication Date


  • 2015

Citation


  • Kenna, N. Mac., Calvert, P., Morrin, A., Wallace, G. G. & Moulton, S. E. (2015). Electro-stimulated release from a reduced graphene oxide composite hydrogel. Journal of Materials Chemistry B, 3 (12), 2530-2537.

Scopus Eid


  • 2-s2.0-84924872596

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1370

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 2530

End Page


  • 2537

Volume


  • 3

Issue


  • 12

Place Of Publication


  • United Kingdom

Abstract


  • Electro-stimulated release was established using a novel, electro-conductive hydrogel system comprising Jeffamine polyetheramine and polyethylene glycol diglycidyl ether (PEGDGE) that was composited with reduced graphene oxide (rGO). The swelling response, morphology, mechanical and electrochemical properties of the composite hydrogel were investigated. Enhanced mechanical and electrical properties were observed with increased rGO content. Passive and electro-stimulated release of methyl orange (MO) from these gels was examined. A significant reduction in passive release of the dye was observed by incorporating rGO. Upon electrical stimulation, the release rate and dosage could be tuned through variation of the % w/w rGO, as well as the polarity and amplitude of the applied electric potential. A high level of control and flexibility was achieved demonstrating the applicability of this system for localised drug delivery applications.

Authors


  •   Kenna, Nicky Mac (external author)
  •   Calvert, Paul D. (external author)
  •   Morrin, Aoife (external author)
  •   Wallace, Gordon G.
  •   Moulton, Simon E. (external author)

Publication Date


  • 2015

Citation


  • Kenna, N. Mac., Calvert, P., Morrin, A., Wallace, G. G. & Moulton, S. E. (2015). Electro-stimulated release from a reduced graphene oxide composite hydrogel. Journal of Materials Chemistry B, 3 (12), 2530-2537.

Scopus Eid


  • 2-s2.0-84924872596

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1370

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 2530

End Page


  • 2537

Volume


  • 3

Issue


  • 12

Place Of Publication


  • United Kingdom