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Osteoblast cell response "in Vitro" on electroactive PVDF films

Conference Paper


Abstract


  • The behavior of cells cultured on substrates is highly dependent on surface

    characteristics, not only chemical composition but also topography, viscoelastic

    properties, electric charge distribution and others. The aim of this work is to study the

    biological response of cells cultured on flat poly(vinylidene fluoride) (PVDF)

    substrates. This material can be obtained in four different crystalline structures, known

    as α, β, γ and δ, depending on the processing conditions [1]. The β-phase is the one with

    the best piezoelectric and pyroelectric properties. The effect of polymer phase (α or β)

    and surface polarization on pre-osteoblasts viability and proliferation will be studied.

    Since one of key factors determining cell adhesion, proliferation and differentiation in

    tissue engineering is the interaction between cells and biomaterials, mediated by the

    proteins adsorbed on the material surface, fibronectin (FN) adsorption on the different

    substrates is quantified and protein conformation analyzed by Atomic Force

    Microscopy (AFM).

UOW Authors


  •   Ribeiro, Clarisse (external author)
  •   Panadero, J A. (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Lanceros-Méndez, Senentxu (external author)
  •   Tamano Machiavello, M N. (external author)
  •   Moratal, David (external author)
  •   Salmerón-Sánchez, Manuel (external author)
  •   Gomez Ribelles, J L. (external author)

Publication Date


  • 2011

Citation


  • Ribeiro, C., Panadero, J. A., Sencadas, V., Lanceros-Méndez, S., Tamano Machiavello, M. N., Moratal, D., Salmerón-Sánchez, M. & Ribelles, J. L. (2011). Osteoblast cell response "in Vitro" on electroactive PVDF films. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials

Scopus Eid


  • 2-s2.0-84887011802

Abstract


  • The behavior of cells cultured on substrates is highly dependent on surface

    characteristics, not only chemical composition but also topography, viscoelastic

    properties, electric charge distribution and others. The aim of this work is to study the

    biological response of cells cultured on flat poly(vinylidene fluoride) (PVDF)

    substrates. This material can be obtained in four different crystalline structures, known

    as α, β, γ and δ, depending on the processing conditions [1]. The β-phase is the one with

    the best piezoelectric and pyroelectric properties. The effect of polymer phase (α or β)

    and surface polarization on pre-osteoblasts viability and proliferation will be studied.

    Since one of key factors determining cell adhesion, proliferation and differentiation in

    tissue engineering is the interaction between cells and biomaterials, mediated by the

    proteins adsorbed on the material surface, fibronectin (FN) adsorption on the different

    substrates is quantified and protein conformation analyzed by Atomic Force

    Microscopy (AFM).

UOW Authors


  •   Ribeiro, Clarisse (external author)
  •   Panadero, J A. (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Lanceros-Méndez, Senentxu (external author)
  •   Tamano Machiavello, M N. (external author)
  •   Moratal, David (external author)
  •   Salmerón-Sánchez, Manuel (external author)
  •   Gomez Ribelles, J L. (external author)

Publication Date


  • 2011

Citation


  • Ribeiro, C., Panadero, J. A., Sencadas, V., Lanceros-Méndez, S., Tamano Machiavello, M. N., Moratal, D., Salmerón-Sánchez, M. & Ribelles, J. L. (2011). Osteoblast cell response "in Vitro" on electroactive PVDF films. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials

Scopus Eid


  • 2-s2.0-84887011802