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Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(l-lactide) electrospun mats

Journal Article


Abstract


  • Poly(l-lactide) electrospun mats have been produced with random and aligned fiber orientation and degrees of crystallinity from 0 up to nearly 50%. These two factors, fiber alignment and degree of crystallinity, strongly affect the hydrophobicity of the samples, this being larger for the aligned fiber mats and for the fibers with a higher degree of crystallinity. Whereas, the first effect can be associated with a decrease in the degree of porosity, the second should be related to an increase in fiber stiffness as the observed fiber roughness variations do not show strong differences between the samples. Proliferation of human chondrocytes cultured in a monolayer on these substrates is similar in both aligned and non-aligned amorphous mats. Crystallization of the aligned mats, on the other hand, nearly suppresses proliferation and the cells produce higher amounts of aggrecan, characteristic of the extracellular matrix of hyaline cartilage. © 2012 The Royal Society of Chemistry.

UOW Authors


  •   Areias, A C. (external author)
  •   Ribeiro, Clarisse (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   García-Giralt, Natàlia (external author)
  •   Díez-Pérez, Adolfo D. (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2012

Citation


  • Areias, A. C., Ribeiro, C., Sencadas, V., García-Giralt, N., Díez-Pérez, A., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2012). Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(l-lactide) electrospun mats. Soft Matter, 8 (21), 5818-5825.

Scopus Eid


  • 2-s2.0-84863199403

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3712

Number Of Pages


  • 7

Start Page


  • 5818

End Page


  • 5825

Volume


  • 8

Issue


  • 21

Abstract


  • Poly(l-lactide) electrospun mats have been produced with random and aligned fiber orientation and degrees of crystallinity from 0 up to nearly 50%. These two factors, fiber alignment and degree of crystallinity, strongly affect the hydrophobicity of the samples, this being larger for the aligned fiber mats and for the fibers with a higher degree of crystallinity. Whereas, the first effect can be associated with a decrease in the degree of porosity, the second should be related to an increase in fiber stiffness as the observed fiber roughness variations do not show strong differences between the samples. Proliferation of human chondrocytes cultured in a monolayer on these substrates is similar in both aligned and non-aligned amorphous mats. Crystallization of the aligned mats, on the other hand, nearly suppresses proliferation and the cells produce higher amounts of aggrecan, characteristic of the extracellular matrix of hyaline cartilage. © 2012 The Royal Society of Chemistry.

UOW Authors


  •   Areias, A C. (external author)
  •   Ribeiro, Clarisse (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   García-Giralt, Natàlia (external author)
  •   Díez-Pérez, Adolfo D. (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2012

Citation


  • Areias, A. C., Ribeiro, C., Sencadas, V., García-Giralt, N., Díez-Pérez, A., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2012). Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(l-lactide) electrospun mats. Soft Matter, 8 (21), 5818-5825.

Scopus Eid


  • 2-s2.0-84863199403

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3712

Number Of Pages


  • 7

Start Page


  • 5818

End Page


  • 5825

Volume


  • 8

Issue


  • 21