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Enhanced proliferation of pre-osteoblastic cells by dynamic piezoelectric stimulation

Journal Article


Abstract


  • This work reports on the influence of the polarization of electroactive poly(vinylidene fluoride), PVDF, on the biological response of cells cultivated under static and dynamic conditions. Non-poled and "poled +" β-PVDF with and without a titanium layer were thus prepared. A thin titanium layer was deposited on PVDF films in order to obtain a more homogeneous surface charge. The MC3T3-E1 osteoblast cell culture exhibited different responses in the presence of PVDF films. The positively charged β-PVDF films promote higher osteoblast adhesion and proliferation, which is higher under dynamic conditions on poled samples, showing that the surface charge under mechanical stimulation improves the osteoblast growth. Therefore, electroactive membranes and scaffolds can provide the necessary electrical stimuli for the growth and proliferation of specific cells. © 2012 The Royal Society of Chemistry.

UOW Authors


  •   Ribeiro, Clarisse (external author)
  •   Moreira, S (external author)
  •   Correia, Vítor (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Rocha, José Gerardo (external author)
  •   Gama, F M. (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2012

Citation


  • Ribeiro, C., Moreira, S., Correia, V., Sencadas, V., Rocha, J. G., Gama, F. M., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2012). Enhanced proliferation of pre-osteoblastic cells by dynamic piezoelectric stimulation. RSC Advances: an international journal to further the chemical sciences, 2 (30), 11504-11509.

Scopus Eid


  • 2-s2.0-84868119547

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3703

Number Of Pages


  • 5

Start Page


  • 11504

End Page


  • 11509

Volume


  • 2

Issue


  • 30

Abstract


  • This work reports on the influence of the polarization of electroactive poly(vinylidene fluoride), PVDF, on the biological response of cells cultivated under static and dynamic conditions. Non-poled and "poled +" β-PVDF with and without a titanium layer were thus prepared. A thin titanium layer was deposited on PVDF films in order to obtain a more homogeneous surface charge. The MC3T3-E1 osteoblast cell culture exhibited different responses in the presence of PVDF films. The positively charged β-PVDF films promote higher osteoblast adhesion and proliferation, which is higher under dynamic conditions on poled samples, showing that the surface charge under mechanical stimulation improves the osteoblast growth. Therefore, electroactive membranes and scaffolds can provide the necessary electrical stimuli for the growth and proliferation of specific cells. © 2012 The Royal Society of Chemistry.

UOW Authors


  •   Ribeiro, Clarisse (external author)
  •   Moreira, S (external author)
  •   Correia, Vítor (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Rocha, José Gerardo (external author)
  •   Gama, F M. (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2012

Citation


  • Ribeiro, C., Moreira, S., Correia, V., Sencadas, V., Rocha, J. G., Gama, F. M., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2012). Enhanced proliferation of pre-osteoblastic cells by dynamic piezoelectric stimulation. RSC Advances: an international journal to further the chemical sciences, 2 (30), 11504-11509.

Scopus Eid


  • 2-s2.0-84868119547

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3703

Number Of Pages


  • 5

Start Page


  • 11504

End Page


  • 11509

Volume


  • 2

Issue


  • 30