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Physical-chemical properties of cross-linked chitosan electrospun fiber mats

Journal Article


Abstract


  • Chitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 ± 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61% for the Protasan material down to 17% for the cross-linking fiber mats. A swelling index up to 1000% was observed for the cross-linked samples. Preliminary MC-3T3-E1cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats.

UOW Authors


  •   Gomes da Silva Sencadas, Vitor
  •   Correia, Daniela M. (external author)
  •   Ribeiro, Clarisse (external author)
  •   Moreira, S (external author)
  •   Botelho, Gabriela (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2012

Citation


  • Sencadas, V., Correia, D. M., Ribeiro, C., Moreira, S., Botelho, G., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2012). Physical-chemical properties of cross-linked chitosan electrospun fiber mats. Polymer Testing, 31 (8), 1062-1069.

Scopus Eid


  • 2-s2.0-84865956186

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3700

Number Of Pages


  • 7

Start Page


  • 1062

End Page


  • 1069

Volume


  • 31

Issue


  • 8

Abstract


  • Chitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 ± 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61% for the Protasan material down to 17% for the cross-linking fiber mats. A swelling index up to 1000% was observed for the cross-linked samples. Preliminary MC-3T3-E1cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats.

UOW Authors


  •   Gomes da Silva Sencadas, Vitor
  •   Correia, Daniela M. (external author)
  •   Ribeiro, Clarisse (external author)
  •   Moreira, S (external author)
  •   Botelho, Gabriela (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2012

Citation


  • Sencadas, V., Correia, D. M., Ribeiro, C., Moreira, S., Botelho, G., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2012). Physical-chemical properties of cross-linked chitosan electrospun fiber mats. Polymer Testing, 31 (8), 1062-1069.

Scopus Eid


  • 2-s2.0-84865956186

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3700

Number Of Pages


  • 7

Start Page


  • 1062

End Page


  • 1069

Volume


  • 31

Issue


  • 8