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Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Journal Article


Abstract


  • Electroactive materials can be taken to advantage for the development of sensors and actuators as well as for novel tissue engineering strategies. Composites based on poly(vinylidene fluoride), PVDF, have been evaluated with respect to their biological response. Cell viability and proliferation were performed in vitro both with Mesenchymal Stem Cells differentiated to osteoblasts and Human Fibroblast Foreskin 1. In vivo tests were also performed using 6-week-old C57Bl/6 mice. It was concluded that zeolite and clay composites are biocompatible materials promoting cell response and not showing in vivo pro-inflammatory effects which renders both of them attractive for biological applications and tissue engineering, opening interesting perspectives to development of scaffolds from these composites. Ferrite and silver nanoparticle composites decrease osteoblast cell viability and carbon nanotubes decrease fibroblast viability. Further, carbon nanotube composites result in a significant increase in local vascularization accompanied an increase of inflammatory markers after implantation. © 2012 Springer Science+Business Media New York.

UOW Authors


  •   Costa, R (external author)
  •   Ribeiro, Clarisse (external author)
  •   Lopes, A C. (external author)
  •   Martins, P (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Soares, R (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2013

Citation


  • Costa, R., Ribeiro, C., Lopes, A. C., Martins, P., Sencadas, V., Soares, R. & Lanceros-Méndez, S. (2013). Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials. Journal of Materials Science: Materials in Medicine, 24 (2), 395-403.

Scopus Eid


  • 2-s2.0-84878353759

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3692

Number Of Pages


  • 8

Start Page


  • 395

End Page


  • 403

Volume


  • 24

Issue


  • 2

Abstract


  • Electroactive materials can be taken to advantage for the development of sensors and actuators as well as for novel tissue engineering strategies. Composites based on poly(vinylidene fluoride), PVDF, have been evaluated with respect to their biological response. Cell viability and proliferation were performed in vitro both with Mesenchymal Stem Cells differentiated to osteoblasts and Human Fibroblast Foreskin 1. In vivo tests were also performed using 6-week-old C57Bl/6 mice. It was concluded that zeolite and clay composites are biocompatible materials promoting cell response and not showing in vivo pro-inflammatory effects which renders both of them attractive for biological applications and tissue engineering, opening interesting perspectives to development of scaffolds from these composites. Ferrite and silver nanoparticle composites decrease osteoblast cell viability and carbon nanotubes decrease fibroblast viability. Further, carbon nanotube composites result in a significant increase in local vascularization accompanied an increase of inflammatory markers after implantation. © 2012 Springer Science+Business Media New York.

UOW Authors


  •   Costa, R (external author)
  •   Ribeiro, Clarisse (external author)
  •   Lopes, A C. (external author)
  •   Martins, P (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Soares, R (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2013

Citation


  • Costa, R., Ribeiro, C., Lopes, A. C., Martins, P., Sencadas, V., Soares, R. & Lanceros-Méndez, S. (2013). Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials. Journal of Materials Science: Materials in Medicine, 24 (2), 395-403.

Scopus Eid


  • 2-s2.0-84878353759

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3692

Number Of Pages


  • 8

Start Page


  • 395

End Page


  • 403

Volume


  • 24

Issue


  • 2