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Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering

Journal Article


Abstract


  • This work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the adhesion and morphology of myoblast cells. Non-poled, "poled+" and "poled-" β-PVDF films were prepared by solvent casting followed by corona poling. Furthermore, random and aligned electrospun β-PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation and that the directional growth of the myoblast cells can be achieved by culturing the cell on aligned fibers. Therefore, the potential application of electroactive materials for muscle regeneration is demonstrated. This journal is © The Royal Society of Chemistry.

UOW Authors


  •   Martins, P (external author)
  •   Ribeiro, S (external author)
  •   Ribeiro, Clarisse (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Gomes, A C. (external author)
  •   Gama, F M. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2013

Citation


  • Martins, P. M., Ribeiro, S., Ribeiro, C., Sencadas, V., Gomes, A. C., Gama, F. M. & Lanceros-Méndez, S. (2013). Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering. RSC Advances, 3 (39), 17938-17944.

Scopus Eid


  • 2-s2.0-84884236535

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3686

Number Of Pages


  • 6

Start Page


  • 17938

End Page


  • 17944

Volume


  • 3

Issue


  • 39

Abstract


  • This work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the adhesion and morphology of myoblast cells. Non-poled, "poled+" and "poled-" β-PVDF films were prepared by solvent casting followed by corona poling. Furthermore, random and aligned electrospun β-PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation and that the directional growth of the myoblast cells can be achieved by culturing the cell on aligned fibers. Therefore, the potential application of electroactive materials for muscle regeneration is demonstrated. This journal is © The Royal Society of Chemistry.

UOW Authors


  •   Martins, P (external author)
  •   Ribeiro, S (external author)
  •   Ribeiro, Clarisse (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Gomes, A C. (external author)
  •   Gama, F M. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2013

Citation


  • Martins, P. M., Ribeiro, S., Ribeiro, C., Sencadas, V., Gomes, A. C., Gama, F. M. & Lanceros-Méndez, S. (2013). Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering. RSC Advances, 3 (39), 17938-17944.

Scopus Eid


  • 2-s2.0-84884236535

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3686

Number Of Pages


  • 6

Start Page


  • 17938

End Page


  • 17944

Volume


  • 3

Issue


  • 39