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Electrosprayed poly(vinylidene fluoride) microparticles for tissue engineering applications

Journal Article


Abstract


  • Poly(vinylidene fluoride) (PVDF) microparticles have been produced by electrospraying as a suitable substrate for tissue engineering applications. The influence of the polymer solution concentration and processing parameters, such as electric field, flow rate and inner needle diameter, on microparticle size and distribution has been studied. Polymer concentration is the most influential parameter on PVDF microparticle formation. Higher concentrations promote the formation of fibers while dilute or semi dilute concentrations favor the formation of PVDF microparticles with average diameters ranging between 0.81 ± 0.34 and 5.55 ± 2.34 μm. Once the formation of microparticles is achieved, no significant differences were found with the variation of other electrospray processing parameters. The electroactive β-phase content, between 63 and 74%, and the crystalline phase content, between 45 and 55%, are mainly independent of the processing parameters. Finally, MC-3T3-E1 cell adhesion on the PVDF microparticles is assessed, indicating their potential use for biomedical applications. This journal is © the Partner Organisations 2014.

UOW Authors


  •   Correia, Daniela M. (external author)
  •   Goncalves, R (external author)
  •   Ribeiro, Clarisse (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Botelho, Gabriela (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2014

Citation


  • Correia, D. M., Gonçalves, R., Ribeiro, C., Sencadas, V., Botelho, G., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2014). Electrosprayed poly(vinylidene fluoride) microparticles for tissue engineering applications. RSC Advances: an international journal to further the chemical sciences, 4 (62), 33013-33021.

Scopus Eid


  • 2-s2.0-84905746205

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3678

Number Of Pages


  • 8

Start Page


  • 33013

End Page


  • 33021

Volume


  • 4

Issue


  • 62

Abstract


  • Poly(vinylidene fluoride) (PVDF) microparticles have been produced by electrospraying as a suitable substrate for tissue engineering applications. The influence of the polymer solution concentration and processing parameters, such as electric field, flow rate and inner needle diameter, on microparticle size and distribution has been studied. Polymer concentration is the most influential parameter on PVDF microparticle formation. Higher concentrations promote the formation of fibers while dilute or semi dilute concentrations favor the formation of PVDF microparticles with average diameters ranging between 0.81 ± 0.34 and 5.55 ± 2.34 μm. Once the formation of microparticles is achieved, no significant differences were found with the variation of other electrospray processing parameters. The electroactive β-phase content, between 63 and 74%, and the crystalline phase content, between 45 and 55%, are mainly independent of the processing parameters. Finally, MC-3T3-E1 cell adhesion on the PVDF microparticles is assessed, indicating their potential use for biomedical applications. This journal is © the Partner Organisations 2014.

UOW Authors


  •   Correia, Daniela M. (external author)
  •   Goncalves, R (external author)
  •   Ribeiro, Clarisse (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Botelho, Gabriela (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2014

Citation


  • Correia, D. M., Gonçalves, R., Ribeiro, C., Sencadas, V., Botelho, G., Gomez Ribelles, J. L. & Lanceros-Méndez, S. (2014). Electrosprayed poly(vinylidene fluoride) microparticles for tissue engineering applications. RSC Advances: an international journal to further the chemical sciences, 4 (62), 33013-33021.

Scopus Eid


  • 2-s2.0-84905746205

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/3678

Number Of Pages


  • 8

Start Page


  • 33013

End Page


  • 33021

Volume


  • 4

Issue


  • 62