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The potential of induced pluripotent stem cells in models of neurological disorders: Implications on future therapy

Journal Article


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Abstract


  • There is an urgent need for new and advanced approaches to modeling the pathological mechanisms of complex human neurological disorders. This is underscored by the decline in pharmaceutical research and development efficiency resulting in a relative decrease in new drug launches in the last several decades. Induced pluripotent stem cells represent a new tool to overcome many of the shortcomings of conventional methods, enabling live human neural cell modeling of complex conditions relating to aberrant neurodevelopment, such as schizophrenia, epilepsy and autism as well as age-associated neurodegeneration. This review considers the current status of induced pluripotent stem cell-based modeling of neurological disorders, canvassing proven and putative advantages, current constraints, and future prospects of next-generation culture systems for biomedical research and translation.

Publication Date


  • 2015

Citation


  • Crook, J. Micah., Wallace, G. & Tomaskovic-Crook, E. (2015). The potential of induced pluripotent stem cells in models of neurological disorders: Implications on future therapy. Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders, 15 (3), 295-304. Expert Review of Neurotherapeutics

Scopus Eid


  • 2-s2.0-84923353444

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2361&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1360

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 295

End Page


  • 304

Volume


  • 15

Issue


  • 3

Place Of Publication


  • United Kingdom

Abstract


  • There is an urgent need for new and advanced approaches to modeling the pathological mechanisms of complex human neurological disorders. This is underscored by the decline in pharmaceutical research and development efficiency resulting in a relative decrease in new drug launches in the last several decades. Induced pluripotent stem cells represent a new tool to overcome many of the shortcomings of conventional methods, enabling live human neural cell modeling of complex conditions relating to aberrant neurodevelopment, such as schizophrenia, epilepsy and autism as well as age-associated neurodegeneration. This review considers the current status of induced pluripotent stem cell-based modeling of neurological disorders, canvassing proven and putative advantages, current constraints, and future prospects of next-generation culture systems for biomedical research and translation.

Publication Date


  • 2015

Citation


  • Crook, J. Micah., Wallace, G. & Tomaskovic-Crook, E. (2015). The potential of induced pluripotent stem cells in models of neurological disorders: Implications on future therapy. Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders, 15 (3), 295-304. Expert Review of Neurotherapeutics

Scopus Eid


  • 2-s2.0-84923353444

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2361&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1360

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 295

End Page


  • 304

Volume


  • 15

Issue


  • 3

Place Of Publication


  • United Kingdom