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No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry

Journal Article


Abstract


  • Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3' flanking region have been shown to be associated with schizophrenia. To replicate these findings, we conducted a family-based association study with the five most significant SNPs in our sample of 79 sib-pair families (56/79 sib-pair families showed linkage to 6q23) and 125 triads. No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples.

UOW Authors


  •   Ludewick, Herbert P. (external author)
  •   Schwab, Sibylle
  •   Albus, Margot (external author)
  •   Lerer, Bernard (external author)
  •   Maier, Wolfgang (external author)
  •   Trixler, Matyas (external author)
  •   Wildenauer, Dieter B. (external author)

Publication Date


  • 2008

Citation


  • Ludewick, H. P., Schwab, S. G., Albus, M., Lerer, B., Maier, W., Trixler, M. & Wildenauer, D. B. (2008). No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. Psychiatric Genetics, 18 (4), 208-210.

Scopus Eid


  • 2-s2.0-50349097153

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/489

Number Of Pages


  • 2

Start Page


  • 208

End Page


  • 210

Volume


  • 18

Issue


  • 4

Abstract


  • Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3' flanking region have been shown to be associated with schizophrenia. To replicate these findings, we conducted a family-based association study with the five most significant SNPs in our sample of 79 sib-pair families (56/79 sib-pair families showed linkage to 6q23) and 125 triads. No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples.

UOW Authors


  •   Ludewick, Herbert P. (external author)
  •   Schwab, Sibylle
  •   Albus, Margot (external author)
  •   Lerer, Bernard (external author)
  •   Maier, Wolfgang (external author)
  •   Trixler, Matyas (external author)
  •   Wildenauer, Dieter B. (external author)

Publication Date


  • 2008

Citation


  • Ludewick, H. P., Schwab, S. G., Albus, M., Lerer, B., Maier, W., Trixler, M. & Wildenauer, D. B. (2008). No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. Psychiatric Genetics, 18 (4), 208-210.

Scopus Eid


  • 2-s2.0-50349097153

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/489

Number Of Pages


  • 2

Start Page


  • 208

End Page


  • 210

Volume


  • 18

Issue


  • 4