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Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms

Journal Article


Abstract


  • Background

    Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT2AR) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT2AR polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients.

    Methods

    We analyzed the 5-HT2AR A-1438G, T102C, and H452Y polymorphisms and assessed startle reactivity, habituation, and PPI of ASR in 68 Caucasian schizophrenia inpatients. Patients were also examined with the Positive and Negative Syndrome Scale.

    Results

    The 5-HT2AR A-1438G and T102C polymorphisms were in complete linkage disequilibrium. Patients carrying the T102C TT and the A-1438G AA allele show significantly higher PPI levels and a faster early habituation compared with all other variants. 5-HT2AR A-1438G and T102C genotype explained approximately 11% of the PPI and early habituation variance. In contrast, the 5-HT2AR H452Y polymorphism did not affect startle parameters.

    Conclusions

    Our findings suggest that PPI and habituation are modulated by 5-HT2AR A-1438G and T102C genotype in schizophrenia. Consequently, alterations within brain 5-HT2ARs may contribute to the PPI deficits in schizophrenia.

UOW Authors


  •   Quednow, Boris B. (external author)
  •   Kuhn, Kai-Uwe (external author)
  •   Mossner, Rainald (external author)
  •   Schwab, Sibylle
  •   Schuhmacher, Anna (external author)
  •   Maier, Wolfgang (external author)
  •   Wagner, Michael (external author)

Publication Date


  • 2008

Citation


  • Quednow, B. B., Kuhn, K., Mossner, R., Schwab, S. G., Schuhmacher, A., Maier, W. & Wagner, M. (2008). Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biological Psychiatry, 64 (5), 434-437.

Scopus Eid


  • 2-s2.0-48949094239

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/485

Number Of Pages


  • 3

Start Page


  • 434

End Page


  • 437

Volume


  • 64

Issue


  • 5

Abstract


  • Background

    Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT2AR) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT2AR polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients.

    Methods

    We analyzed the 5-HT2AR A-1438G, T102C, and H452Y polymorphisms and assessed startle reactivity, habituation, and PPI of ASR in 68 Caucasian schizophrenia inpatients. Patients were also examined with the Positive and Negative Syndrome Scale.

    Results

    The 5-HT2AR A-1438G and T102C polymorphisms were in complete linkage disequilibrium. Patients carrying the T102C TT and the A-1438G AA allele show significantly higher PPI levels and a faster early habituation compared with all other variants. 5-HT2AR A-1438G and T102C genotype explained approximately 11% of the PPI and early habituation variance. In contrast, the 5-HT2AR H452Y polymorphism did not affect startle parameters.

    Conclusions

    Our findings suggest that PPI and habituation are modulated by 5-HT2AR A-1438G and T102C genotype in schizophrenia. Consequently, alterations within brain 5-HT2ARs may contribute to the PPI deficits in schizophrenia.

UOW Authors


  •   Quednow, Boris B. (external author)
  •   Kuhn, Kai-Uwe (external author)
  •   Mossner, Rainald (external author)
  •   Schwab, Sibylle
  •   Schuhmacher, Anna (external author)
  •   Maier, Wolfgang (external author)
  •   Wagner, Michael (external author)

Publication Date


  • 2008

Citation


  • Quednow, B. B., Kuhn, K., Mossner, R., Schwab, S. G., Schuhmacher, A., Maier, W. & Wagner, M. (2008). Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biological Psychiatry, 64 (5), 434-437.

Scopus Eid


  • 2-s2.0-48949094239

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/485

Number Of Pages


  • 3

Start Page


  • 434

End Page


  • 437

Volume


  • 64

Issue


  • 5