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Gross morphological brain changes with chronic, heavy cannabis use

Journal Article


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Abstract


  • We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric comorbidity or significant exposure to other substances (compared with 15 age- and IQ-matched non-cannabis-using controls) using manual techniques. Heavy cannabis users demonstrated smaller hippocampus and amygdala volumes, but no alterations of the orbitofrontal and anterior- and paracingulate cortices, or the pituitary gland. These findings indicate that chronic cannabis use has a selective and detrimental impact on the morphology of the mediotemporal lobe.

UOW Authors


  •   Lorenzetti, Valentina (external author)
  •   Solowij, Nadia
  •   Whittle, Sarah (external author)
  •   Fornito, Alex (external author)
  •   Lubman, Daniel I. (external author)
  •   Pantelis, Christos (external author)
  •   Yucel, Murat (external author)

Publication Date


  • 2015

Citation


  • Lorenzetti, V., Solowij, N., Whittle, S., Fornito, A., Lubman, D. I., Pantelis, C. & Yücel, M. (2015). Gross morphological brain changes with chronic, heavy cannabis use. British Journal of Psychiatry, 206 (1), 77-78.

Scopus Eid


  • 2-s2.0-84920448489

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2305&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/1306

Has Global Citation Frequency


Number Of Pages


  • 1

Start Page


  • 77

End Page


  • 78

Volume


  • 206

Issue


  • 1

Place Of Publication


  • United Kingdom

Abstract


  • We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric comorbidity or significant exposure to other substances (compared with 15 age- and IQ-matched non-cannabis-using controls) using manual techniques. Heavy cannabis users demonstrated smaller hippocampus and amygdala volumes, but no alterations of the orbitofrontal and anterior- and paracingulate cortices, or the pituitary gland. These findings indicate that chronic cannabis use has a selective and detrimental impact on the morphology of the mediotemporal lobe.

UOW Authors


  •   Lorenzetti, Valentina (external author)
  •   Solowij, Nadia
  •   Whittle, Sarah (external author)
  •   Fornito, Alex (external author)
  •   Lubman, Daniel I. (external author)
  •   Pantelis, Christos (external author)
  •   Yucel, Murat (external author)

Publication Date


  • 2015

Citation


  • Lorenzetti, V., Solowij, N., Whittle, S., Fornito, A., Lubman, D. I., Pantelis, C. & Yücel, M. (2015). Gross morphological brain changes with chronic, heavy cannabis use. British Journal of Psychiatry, 206 (1), 77-78.

Scopus Eid


  • 2-s2.0-84920448489

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2305&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/1306

Has Global Citation Frequency


Number Of Pages


  • 1

Start Page


  • 77

End Page


  • 78

Volume


  • 206

Issue


  • 1

Place Of Publication


  • United Kingdom