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Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities

Journal Article


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Abstract


  • Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S*),12(R*)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.

UOW Authors


  •   Ramli, Rosdayati Alino (external author)
  •   Pudjiastuti, Pratiwi (external author)
  •   Tjahjandaric, Tjitjik S. (external author)
  •   Lie, Wilford
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Pyne, Stephen

Publication Date


  • 2015

Citation


  • Ramli, R., Pudjiastuti, P., Tjahjandaric, T. S., Lie, W., Rattanajak, R., Kamchonwongpaisan, S. & Pyne, S. G. (2015). Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities. Phytochemistry Letters, 11 157-162.

Scopus Eid


  • 2-s2.0-84920085367

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3872&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2850

Number Of Pages


  • 5

Start Page


  • 157

End Page


  • 162

Volume


  • 11

Abstract


  • Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S*),12(R*)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.

UOW Authors


  •   Ramli, Rosdayati Alino (external author)
  •   Pudjiastuti, Pratiwi (external author)
  •   Tjahjandaric, Tjitjik S. (external author)
  •   Lie, Wilford
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Pyne, Stephen

Publication Date


  • 2015

Citation


  • Ramli, R., Pudjiastuti, P., Tjahjandaric, T. S., Lie, W., Rattanajak, R., Kamchonwongpaisan, S. & Pyne, S. G. (2015). Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities. Phytochemistry Letters, 11 157-162.

Scopus Eid


  • 2-s2.0-84920085367

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3872&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2850

Number Of Pages


  • 5

Start Page


  • 157

End Page


  • 162

Volume


  • 11