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A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Journal Article


Abstract


  • Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Authors


  •   Sanderson-Smith, Martina L.
  •   De Oliveira, David (external author)
  •   Guglielmini, Julien (external author)
  •   McMillan, David J. (external author)
  •   Vu, Therese (external author)
  •   Holien, Jessica K. (external author)
  •   Henningham, Anna (external author)
  •   Steer, Andrew C. (external author)
  •   Bessen, Debra E. (external author)
  •   Dale, James B. (external author)
  •   Curtis, Nigel (external author)
  •   Beall, Bernard W. (external author)
  •   Walker, Mark J. (external author)
  •   Parker, Michael W. (external author)
  •   Carapetis, Jonathan R. (external author)
  •   Van Melderen, Laurence (external author)
  •   Sriprakash, Kadaba S. (external author)
  •   Smeesters, Pierre R. (external author)
  •   Protein Study Group, M (external author)

Publication Date


  • 2014

Citation


  • Sanderson-Smith, M., De Oliveira, D. M. P., Guglielmini, J., McMillan, D. J., Vu, T., Holien, J. K., Henningham, A., Steer, A. C., Bessen, D. E., Dale, J. B., Curtis, N., Beall, B. W., Walker, M. J., Parker, M. W., Carapetis, J. R., Van Melderen, L., Sriprakash, K. S., Smeesters, P. R. & Protein Study Group, M. (2014). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. Journal of Infectious Diseases, 210 (8), 1325-1338.

Scopus Eid


  • 2-s2.0-84910012882

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/499

Has Global Citation Frequency


Number Of Pages


  • 13

Start Page


  • 1325

End Page


  • 1338

Volume


  • 210

Issue


  • 8

Place Of Publication


  • United States

Abstract


  • Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Authors


  •   Sanderson-Smith, Martina L.
  •   De Oliveira, David (external author)
  •   Guglielmini, Julien (external author)
  •   McMillan, David J. (external author)
  •   Vu, Therese (external author)
  •   Holien, Jessica K. (external author)
  •   Henningham, Anna (external author)
  •   Steer, Andrew C. (external author)
  •   Bessen, Debra E. (external author)
  •   Dale, James B. (external author)
  •   Curtis, Nigel (external author)
  •   Beall, Bernard W. (external author)
  •   Walker, Mark J. (external author)
  •   Parker, Michael W. (external author)
  •   Carapetis, Jonathan R. (external author)
  •   Van Melderen, Laurence (external author)
  •   Sriprakash, Kadaba S. (external author)
  •   Smeesters, Pierre R. (external author)
  •   Protein Study Group, M (external author)

Publication Date


  • 2014

Citation


  • Sanderson-Smith, M., De Oliveira, D. M. P., Guglielmini, J., McMillan, D. J., Vu, T., Holien, J. K., Henningham, A., Steer, A. C., Bessen, D. E., Dale, J. B., Curtis, N., Beall, B. W., Walker, M. J., Parker, M. W., Carapetis, J. R., Van Melderen, L., Sriprakash, K. S., Smeesters, P. R. & Protein Study Group, M. (2014). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. Journal of Infectious Diseases, 210 (8), 1325-1338.

Scopus Eid


  • 2-s2.0-84910012882

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/499

Has Global Citation Frequency


Number Of Pages


  • 13

Start Page


  • 1325

End Page


  • 1338

Volume


  • 210

Issue


  • 8

Place Of Publication


  • United States