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Cancer biology: molecular and genetic basis

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Abstract


  • Cancer is a disease of uncontrolled growth and proliferation whereby cells have escaped the body’s normal growth control mechanisms and have gained the ability to divide indefinitely. It is a multi-step process that requires the accumulation of many genetic changes over time (Figure 1). These genetic alterations involve activation of proto-oncogenes to oncogenes, deregulation of tumour suppressor genes and DNA repair genes and ‘immortalisation’ which will be discussed in this chapter.

UOW Authors


  •   Bommer, Ulrich A.. (external author)
  •   Perrow, Kara
  •   Cancer Council Australia, Oncology Education Committee (external author)

Publication Date


  • 2014

Citation


  • Bommer, U., Vine, K. L. & Cancer Council Australia, O. (2014). Cancer biology: molecular and genetic basis. In S. Sabesan, I. Olver & O. Cancer Council Australia (Eds.), Clinical Oncology for Medical Students (p. On Line). Sydney: Cancer Council Australia Oncology Education Committee. http://wiki.cancer.org.au/oncologyformedicalstudents/Cancer_biology:_Molecular_and_genetic_basis

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1495&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/478

Book Title


  • Clinical Oncology for Medical Students

Start Page


  • On Line

Place Of Publication


  • Sydney

Abstract


  • Cancer is a disease of uncontrolled growth and proliferation whereby cells have escaped the body’s normal growth control mechanisms and have gained the ability to divide indefinitely. It is a multi-step process that requires the accumulation of many genetic changes over time (Figure 1). These genetic alterations involve activation of proto-oncogenes to oncogenes, deregulation of tumour suppressor genes and DNA repair genes and ‘immortalisation’ which will be discussed in this chapter.

UOW Authors


  •   Bommer, Ulrich A.. (external author)
  •   Perrow, Kara
  •   Cancer Council Australia, Oncology Education Committee (external author)

Publication Date


  • 2014

Citation


  • Bommer, U., Vine, K. L. & Cancer Council Australia, O. (2014). Cancer biology: molecular and genetic basis. In S. Sabesan, I. Olver & O. Cancer Council Australia (Eds.), Clinical Oncology for Medical Students (p. On Line). Sydney: Cancer Council Australia Oncology Education Committee. http://wiki.cancer.org.au/oncologyformedicalstudents/Cancer_biology:_Molecular_and_genetic_basis

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1495&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/478

Book Title


  • Clinical Oncology for Medical Students

Start Page


  • On Line

Place Of Publication


  • Sydney