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Serotonintransportergen und stressreagibilität bei unipolarer depression

Journal Article


Abstract


  • Background

    A length polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with both depression and hypothalamic-pituitary-adrenal (HPA) system activity. A dysregulation of the HPA system is considered to be a candidate endophenotype of depression. The objective of the present study was an investigation of a possible gene-endophenotype-interaction between 5-HTTLPR and HPA system activity in a sample of inpatients with major depression.

    Materials and methods

    A total of 237 inpatients with major depression were genotyped for 5-HTTLPR and participated in a combined dexamethasone-corticotropin-releasing hormone test (Dex-CRH test) as well as using the Hamilton score (Hamilton rating scale for depression) to determine the severity of the psychopathology.

    Results

    Patients with the ss-genotype showed a significantly higher HPA -system activity in comparison to patients with the lI–genotype, but no association between 5-HTTLPR and the severity of psychopathology could be detected.

    Conclusions

    The results of the current study demonstrate an influence of 5-HTTLPR on dysregulation of the HPA system in patients with major depression and support the hypothesis that 5-HTTLPR- and HPA-system-interaction constitutes an important component in the pathogenesis of depression.

UOW Authors


  •   Welper, Hanne (external author)
  •   Aller, A (external author)
  •   Guttenthaler, Vera (external author)
  •   Hofels, Susanne (external author)
  •   Lennertz, Leonhard (external author)
  •   Pfeiffer, Ute (external author)
  •   Schwab, Sibylle
  •   Zobel, Astrid W. (external author)

Publication Date


  • 2014

Geographic Focus


Citation


  • Welper, H., Aller, A., Guttenthaler, V., Hofels, S., Lennertz, L., Pfeiffer, U., Schwab, S. G. & Zobel, A. W. (2014). Serotonintransportergen und stressreagibilität bei unipolarer depression. Der Nervenarzt: Monatsschrift fuer alle Gebiete nervenaerztlicher Forschung und Praxis, 85 (3), 336-343.

Scopus Eid


  • 2-s2.0-84898044822

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/466

Number Of Pages


  • 7

Start Page


  • 336

End Page


  • 343

Volume


  • 85

Issue


  • 3

Abstract


  • Background

    A length polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with both depression and hypothalamic-pituitary-adrenal (HPA) system activity. A dysregulation of the HPA system is considered to be a candidate endophenotype of depression. The objective of the present study was an investigation of a possible gene-endophenotype-interaction between 5-HTTLPR and HPA system activity in a sample of inpatients with major depression.

    Materials and methods

    A total of 237 inpatients with major depression were genotyped for 5-HTTLPR and participated in a combined dexamethasone-corticotropin-releasing hormone test (Dex-CRH test) as well as using the Hamilton score (Hamilton rating scale for depression) to determine the severity of the psychopathology.

    Results

    Patients with the ss-genotype showed a significantly higher HPA -system activity in comparison to patients with the lI–genotype, but no association between 5-HTTLPR and the severity of psychopathology could be detected.

    Conclusions

    The results of the current study demonstrate an influence of 5-HTTLPR on dysregulation of the HPA system in patients with major depression and support the hypothesis that 5-HTTLPR- and HPA-system-interaction constitutes an important component in the pathogenesis of depression.

UOW Authors


  •   Welper, Hanne (external author)
  •   Aller, A (external author)
  •   Guttenthaler, Vera (external author)
  •   Hofels, Susanne (external author)
  •   Lennertz, Leonhard (external author)
  •   Pfeiffer, Ute (external author)
  •   Schwab, Sibylle
  •   Zobel, Astrid W. (external author)

Publication Date


  • 2014

Geographic Focus


Citation


  • Welper, H., Aller, A., Guttenthaler, V., Hofels, S., Lennertz, L., Pfeiffer, U., Schwab, S. G. & Zobel, A. W. (2014). Serotonintransportergen und stressreagibilität bei unipolarer depression. Der Nervenarzt: Monatsschrift fuer alle Gebiete nervenaerztlicher Forschung und Praxis, 85 (3), 336-343.

Scopus Eid


  • 2-s2.0-84898044822

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/466

Number Of Pages


  • 7

Start Page


  • 336

End Page


  • 343

Volume


  • 85

Issue


  • 3