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Efficient synthesis and antioxidant activity of coelenterazine analogues

Journal Article


Abstract


  • A convenient and highly convergent method for the synthesis of new imidazo[1,2-a]pyridine-based coelenterazine analogues is reported. The imidazo[1,2-a]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals. Additionally, a new approach to the synthesis of benzylglyoxals was introduced. The imidazo[1,2-a]pyridines display moderate antioxidant activities at a low micromolar level in 2,2-diphenyl-1-picrylhydrazyl (DPPH).

Publication Date


  • 2014

Citation


  • Lu, Y., Hendra, R., Oakley, A. J. & Keller, P. A. (2014). Efficient synthesis and antioxidant activity of coelenterazine analogues. Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 55 (45), 6212-6215.

Scopus Eid


  • 2-s2.0-84908249274

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2604

Number Of Pages


  • 3

Start Page


  • 6212

End Page


  • 6215

Volume


  • 55

Issue


  • 45

Abstract


  • A convenient and highly convergent method for the synthesis of new imidazo[1,2-a]pyridine-based coelenterazine analogues is reported. The imidazo[1,2-a]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals. Additionally, a new approach to the synthesis of benzylglyoxals was introduced. The imidazo[1,2-a]pyridines display moderate antioxidant activities at a low micromolar level in 2,2-diphenyl-1-picrylhydrazyl (DPPH).

Publication Date


  • 2014

Citation


  • Lu, Y., Hendra, R., Oakley, A. J. & Keller, P. A. (2014). Efficient synthesis and antioxidant activity of coelenterazine analogues. Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 55 (45), 6212-6215.

Scopus Eid


  • 2-s2.0-84908249274

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2604

Number Of Pages


  • 3

Start Page


  • 6212

End Page


  • 6215

Volume


  • 55

Issue


  • 45