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Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia

Journal Article


Abstract


  • Background

    Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background.

    Methods

    We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR–RFLP assay for confirmation of rs1344706 genotypes.

    Results

    We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95%, CI 1.025–1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706.

    Conclusion

    We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.

UOW Authors


  •   Schwab, Sibylle
  •   Kusumawardhani, Agung A.A.A. (external author)
  •   Dai, Nan (external author)
  •   Qin, Wenwen (external author)
  •   Wildenauer, Mutiara D.B. (external author)
  •   Agiananda, Feranindhya (external author)
  •   Amir, Nurmiati (external author)
  •   Antoni, Ronald (external author)
  •   Arsianti, Tiana (external author)
  •   Asmarahadi, Asmarahadi (external author)
  •   Diatri, Hervita (external author)
  •   Djatmiko, Prianto (external author)
  •   Irmansyah, Irmansyah (external author)
  •   Khalimah, Siti (external author)
  •   Kusumadewi, Irmia (external author)
  •   Kusumaningrum, Profitasari (external author)
  •   Lukman, Petrin R. (external author)
  •   Mustar, Lukman (external author)
  •   Nasrun, Martina W. (external author)
  •   Naswati, Safyuni (external author)
  •   Prasetiyawan, Prasetiyawan (external author)
  •   Semen, Gerald M. (external author)
  •   Siste, Kristiana (external author)
  •   Tobing, Heriani (external author)
  •   Widiasih, Natalia (external author)
  •   Wiguna, Tjhin (external author)
  •   Wulandari, Widayanti Dewi (external author)
  •   Indonesian Schizophrenia Genetics Consortium, - (external author)
  •   Benyamin, Beben (external author)
  •   Wildenauer, Dieter B. (external author)

Publication Date


  • 2013

Citation


  • Schwab, S. G., Kusumawardhani, A. A.A.A., Dai, N., Qin, W., Wildenauer, M. D.B., Agiananda, F., Amir, N., Antoni, R., Arsianti, T., Asmarahadi, A., Diatri, H., Djatmiko, P., Irmansyah, I., Khalimah, S., Kusumadewi, I., Kusumaningrum, P., Lukman, P. R., Mustar, L., Nasrun, M. W., Naswati, S., Prasetiyawan, P., Semen, G. M., Siste, K., Tobing, H., Widiasih, N., Wiguna, T., Wulandari, W., Indonesian Schizophrenia Genetics Consortium, , Benyamin, B. & Wildenauer, D. B. (2013). Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. Schizophrenia Research, 147 (1), 46-52.

Scopus Eid


  • 2-s2.0-84877105082

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/455

Number Of Pages


  • 6

Start Page


  • 46

End Page


  • 52

Volume


  • 147

Issue


  • 1

Abstract


  • Background

    Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background.

    Methods

    We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR–RFLP assay for confirmation of rs1344706 genotypes.

    Results

    We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95%, CI 1.025–1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706.

    Conclusion

    We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.

UOW Authors


  •   Schwab, Sibylle
  •   Kusumawardhani, Agung A.A.A. (external author)
  •   Dai, Nan (external author)
  •   Qin, Wenwen (external author)
  •   Wildenauer, Mutiara D.B. (external author)
  •   Agiananda, Feranindhya (external author)
  •   Amir, Nurmiati (external author)
  •   Antoni, Ronald (external author)
  •   Arsianti, Tiana (external author)
  •   Asmarahadi, Asmarahadi (external author)
  •   Diatri, Hervita (external author)
  •   Djatmiko, Prianto (external author)
  •   Irmansyah, Irmansyah (external author)
  •   Khalimah, Siti (external author)
  •   Kusumadewi, Irmia (external author)
  •   Kusumaningrum, Profitasari (external author)
  •   Lukman, Petrin R. (external author)
  •   Mustar, Lukman (external author)
  •   Nasrun, Martina W. (external author)
  •   Naswati, Safyuni (external author)
  •   Prasetiyawan, Prasetiyawan (external author)
  •   Semen, Gerald M. (external author)
  •   Siste, Kristiana (external author)
  •   Tobing, Heriani (external author)
  •   Widiasih, Natalia (external author)
  •   Wiguna, Tjhin (external author)
  •   Wulandari, Widayanti Dewi (external author)
  •   Indonesian Schizophrenia Genetics Consortium, - (external author)
  •   Benyamin, Beben (external author)
  •   Wildenauer, Dieter B. (external author)

Publication Date


  • 2013

Citation


  • Schwab, S. G., Kusumawardhani, A. A.A.A., Dai, N., Qin, W., Wildenauer, M. D.B., Agiananda, F., Amir, N., Antoni, R., Arsianti, T., Asmarahadi, A., Diatri, H., Djatmiko, P., Irmansyah, I., Khalimah, S., Kusumadewi, I., Kusumaningrum, P., Lukman, P. R., Mustar, L., Nasrun, M. W., Naswati, S., Prasetiyawan, P., Semen, G. M., Siste, K., Tobing, H., Widiasih, N., Wiguna, T., Wulandari, W., Indonesian Schizophrenia Genetics Consortium, , Benyamin, B. & Wildenauer, D. B. (2013). Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. Schizophrenia Research, 147 (1), 46-52.

Scopus Eid


  • 2-s2.0-84877105082

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/455

Number Of Pages


  • 6

Start Page


  • 46

End Page


  • 52

Volume


  • 147

Issue


  • 1