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Single molecule studies of nucleic acid enzymes

Chapter


Abstract


  • The replication, transcription, recombination, and repair of DNA are essential processes

    in the propagation, utilization, and upkeep of genetic information. Numerous different

    enzymes have evolved to catalyze the synthesis, digestion, unwinding, and unlinking

    of nucleic acids that are central to genomic maintenance. The development of single

    molecule techniques has allowed researchers to study the activity of nucleic acid enzymes

    at an unprecedented level of detail. This chapter will review the various experimental

    methods used and will discuss the type of information obtained by the study of nucleic

    acid enzymes at the single molecule level.

Publication Date


  • 2009

Citation


  • Hamdan, S. M. & van Oijen, A. M. (2009). Single molecule studies of nucleic acid enzymes. In A. E. Knight (Eds.), Single Molecule Biology (pp. 173-193). San Diego: Elsevier.

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2280

Book Title


  • Single Molecule Biology

Start Page


  • 173

End Page


  • 193

Abstract


  • The replication, transcription, recombination, and repair of DNA are essential processes

    in the propagation, utilization, and upkeep of genetic information. Numerous different

    enzymes have evolved to catalyze the synthesis, digestion, unwinding, and unlinking

    of nucleic acids that are central to genomic maintenance. The development of single

    molecule techniques has allowed researchers to study the activity of nucleic acid enzymes

    at an unprecedented level of detail. This chapter will review the various experimental

    methods used and will discuss the type of information obtained by the study of nucleic

    acid enzymes at the single molecule level.

Publication Date


  • 2009

Citation


  • Hamdan, S. M. & van Oijen, A. M. (2009). Single molecule studies of nucleic acid enzymes. In A. E. Knight (Eds.), Single Molecule Biology (pp. 173-193). San Diego: Elsevier.

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2280

Book Title


  • Single Molecule Biology

Start Page


  • 173

End Page


  • 193