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Cutting the forest to see a single tree?

Journal Article


Abstract


  • The development of single-molecule tools has significantly impacted the way we think about biochemical processes. Watching a single protein in action allows us to observe kinetic details and rare subpopulations that are hidden in ensemble-averaging techniques. I will discuss here the pros and cons of the single-molecule approach in studying ligand binding in macromolecular systems and how these techniques can be applied to characterize the behavior of large multicomponent biochemical systems.

Publication Date


  • 2008

Citation


  • van Oijen, A. M. (2008). Cutting the forest to see a single tree?. Nature Chemical Biology, 4 (8), 440-443.

Scopus Eid


  • 2-s2.0-47649091426

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2201

Number Of Pages


  • 3

Start Page


  • 440

End Page


  • 443

Volume


  • 4

Issue


  • 8

Abstract


  • The development of single-molecule tools has significantly impacted the way we think about biochemical processes. Watching a single protein in action allows us to observe kinetic details and rare subpopulations that are hidden in ensemble-averaging techniques. I will discuss here the pros and cons of the single-molecule approach in studying ligand binding in macromolecular systems and how these techniques can be applied to characterize the behavior of large multicomponent biochemical systems.

Publication Date


  • 2008

Citation


  • van Oijen, A. M. (2008). Cutting the forest to see a single tree?. Nature Chemical Biology, 4 (8), 440-443.

Scopus Eid


  • 2-s2.0-47649091426

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2201

Number Of Pages


  • 3

Start Page


  • 440

End Page


  • 443

Volume


  • 4

Issue


  • 8