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A single-molecule view of DNA replication: the dynamic nature of multi-protein complexes revealed

Journal Article


Abstract


  • Recent advances in the development of single-molecule approaches have made it possible to study the dynamics of biomolecular systems in great detail. More recently, such tools have been applied to study the dynamic nature of large multi-protein complexes that support multiple enzymatic activities. In this review, we will discuss single-molecule studies of the replisome, the protein complex responsible for the coordinated replication of double-stranded DNA. In particular, we will focus on new insights obtained into the dynamic nature of the composition of the DNA-replication machinery and how the dynamic replacement of components plays a role in the regulation of the DNA-replication process.

Publication Date


  • 2013

Citation


  • Geertsema, H. J. & van Oijen, A. M. (2013). A single-molecule view of DNA replication: the dynamic nature of multi-protein complexes revealed. Current Opinion in Structural Biology, 23 (5), 788-793.

Scopus Eid


  • 2-s2.0-84885869576

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2158

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 788

End Page


  • 793

Volume


  • 23

Issue


  • 5

Place Of Publication


  • United Kingdom

Abstract


  • Recent advances in the development of single-molecule approaches have made it possible to study the dynamics of biomolecular systems in great detail. More recently, such tools have been applied to study the dynamic nature of large multi-protein complexes that support multiple enzymatic activities. In this review, we will discuss single-molecule studies of the replisome, the protein complex responsible for the coordinated replication of double-stranded DNA. In particular, we will focus on new insights obtained into the dynamic nature of the composition of the DNA-replication machinery and how the dynamic replacement of components plays a role in the regulation of the DNA-replication process.

Publication Date


  • 2013

Citation


  • Geertsema, H. J. & van Oijen, A. M. (2013). A single-molecule view of DNA replication: the dynamic nature of multi-protein complexes revealed. Current Opinion in Structural Biology, 23 (5), 788-793.

Scopus Eid


  • 2-s2.0-84885869576

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2158

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 788

End Page


  • 793

Volume


  • 23

Issue


  • 5

Place Of Publication


  • United Kingdom