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Mechanisms of hemagglutinin targeted influenza virus neutralization

Journal Article


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Abstract


  • Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preventing the proteolytic activation of HA. HA-head binding antibodies prevent viral attachment and release. These insights into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals.

Authors


  •   Brandenburg, Boerries (external author)
  •   Koudstaal, Wouter (external author)
  •   Goudsmit, Jaap (external author)
  •   Klaren, Vincent (external author)
  •   Tang, Chan (external author)
  •   Bujny, Miriam V. (external author)
  •   Korse, Hans J.W.M. (external author)
  •   Kwaks, Ted (external author)
  •   Otterstrom, Jason J. (external author)
  •   Juraszek, Jarek (external author)
  •   van Oijen, Antoine M.
  •   Vogels, Ronald (external author)
  •   Friesen, Robert H. E. (external author)

Publication Date


  • 2013

Citation


  • Brandenburg, B., Koudstaal, W., Goudsmit, J., Klaren, V., Tang, C., Bujny, M. V., Korse, H. J.W.M., Kwaks, T., Otterstrom, J. J., Juraszek, J., van Oijen, A. M., Vogels, R. & Friesen, R. H. E. (2013). Mechanisms of hemagglutinin targeted influenza virus neutralization. PLoS One, 8 (12), e80034-1-e80034-14.

Scopus Eid


  • 2-s2.0-84892615764

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3174&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2156

Has Global Citation Frequency


Start Page


  • e80034-1

End Page


  • e80034-14

Volume


  • 8

Issue


  • 12

Place Of Publication


  • United States

Abstract


  • Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preventing the proteolytic activation of HA. HA-head binding antibodies prevent viral attachment and release. These insights into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals.

Authors


  •   Brandenburg, Boerries (external author)
  •   Koudstaal, Wouter (external author)
  •   Goudsmit, Jaap (external author)
  •   Klaren, Vincent (external author)
  •   Tang, Chan (external author)
  •   Bujny, Miriam V. (external author)
  •   Korse, Hans J.W.M. (external author)
  •   Kwaks, Ted (external author)
  •   Otterstrom, Jason J. (external author)
  •   Juraszek, Jarek (external author)
  •   van Oijen, Antoine M.
  •   Vogels, Ronald (external author)
  •   Friesen, Robert H. E. (external author)

Publication Date


  • 2013

Citation


  • Brandenburg, B., Koudstaal, W., Goudsmit, J., Klaren, V., Tang, C., Bujny, M. V., Korse, H. J.W.M., Kwaks, T., Otterstrom, J. J., Juraszek, J., van Oijen, A. M., Vogels, R. & Friesen, R. H. E. (2013). Mechanisms of hemagglutinin targeted influenza virus neutralization. PLoS One, 8 (12), e80034-1-e80034-14.

Scopus Eid


  • 2-s2.0-84892615764

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3174&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2156

Has Global Citation Frequency


Start Page


  • e80034-1

End Page


  • e80034-14

Volume


  • 8

Issue


  • 12

Place Of Publication


  • United States