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Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia

Journal Article


Abstract


  • Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in schizophrenia. We characterized mGluR2 and 3 mRNA in the human prefrontal cortex (PFC) and mesencephalon, and then compared cases with schizophrenia to matched controls. In the human brain, both receptors were expressed in the PFC and, unlike the rodent, in dopaminergic (DA) cell groups. In schizophrenia, we found significantly higher levels of mGluR2 mRNA in the PFC white matter. The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia.

Authors


  •   Ghose, Subroto (external author)
  •   Crook, Jeremy M.
  •   Bartus, Cynthia L. (external author)
  •   Sherman, Thomas G. (external author)
  •   Herman, Mary M. (external author)
  •   Hyde, Thomas M. (external author)
  •   Kleinman, Joel E. (external author)
  •   Akil, Mayada (external author)

Publication Date


  • 2008

Citation


  • Ghose, S., Crook, J. M., Bartus, C. L., Sherman, T. G., Herman, M. M., Hyde, T. M., Kleinman, J. E. & Akil, M. (2008). Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia. International Journal of Neuroscience, 118 (11), 1609-1627.

Scopus Eid


  • 2-s2.0-53949094531

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1189

Has Global Citation Frequency


Number Of Pages


  • 18

Start Page


  • 1609

End Page


  • 1627

Volume


  • 118

Issue


  • 11

Place Of Publication


  • United Kingdom

Abstract


  • Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in schizophrenia. We characterized mGluR2 and 3 mRNA in the human prefrontal cortex (PFC) and mesencephalon, and then compared cases with schizophrenia to matched controls. In the human brain, both receptors were expressed in the PFC and, unlike the rodent, in dopaminergic (DA) cell groups. In schizophrenia, we found significantly higher levels of mGluR2 mRNA in the PFC white matter. The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia.

Authors


  •   Ghose, Subroto (external author)
  •   Crook, Jeremy M.
  •   Bartus, Cynthia L. (external author)
  •   Sherman, Thomas G. (external author)
  •   Herman, Mary M. (external author)
  •   Hyde, Thomas M. (external author)
  •   Kleinman, Joel E. (external author)
  •   Akil, Mayada (external author)

Publication Date


  • 2008

Citation


  • Ghose, S., Crook, J. M., Bartus, C. L., Sherman, T. G., Herman, M. M., Hyde, T. M., Kleinman, J. E. & Akil, M. (2008). Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia. International Journal of Neuroscience, 118 (11), 1609-1627.

Scopus Eid


  • 2-s2.0-53949094531

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1189

Has Global Citation Frequency


Number Of Pages


  • 18

Start Page


  • 1609

End Page


  • 1627

Volume


  • 118

Issue


  • 11

Place Of Publication


  • United Kingdom