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Human stem cells for modeling neurological disorders: accelerating the drug discovery pipeline

Journal Article


Abstract


  • The availability of human stem cells heralds a new era for modeling normal and pathologic tissues and developing therapeutics. For example, the in vitro recapitulation of normal and aberrant neurogenesis holds significant promise as a tool for de novo modeling of neurodevelopmental and neurodegenerative diseases. Translational applications include deciphering brain development, function, pathologies, traditional medications, and drug discovery for novel pharmacotherapeutics. For the latter, human stem cell-based assays represent a physiologically relevant and high-throughput means to assess toxicity and other undesirable effects early in the drug development pipeline, avoiding late-stage attrition whilst expediting proof-of-concept of genuine drug candidates. Here we consider the potential of human embryonic, adult, and induced pluripotent stem cells for studying neurological disorders and preclinical drug development.

Publication Date


  • 2008

Citation


  • Crook, J. Micah. & Kobayashi, N. Rei. (2008). Human stem cells for modeling neurological disorders: accelerating the drug discovery pipeline. Journal of Cellular Biochemistry, 105 (6), 1361-1366.

Scopus Eid


  • 2-s2.0-57349129017

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1187

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 1361

End Page


  • 1366

Volume


  • 105

Issue


  • 6

Place Of Publication


  • United States

Abstract


  • The availability of human stem cells heralds a new era for modeling normal and pathologic tissues and developing therapeutics. For example, the in vitro recapitulation of normal and aberrant neurogenesis holds significant promise as a tool for de novo modeling of neurodevelopmental and neurodegenerative diseases. Translational applications include deciphering brain development, function, pathologies, traditional medications, and drug discovery for novel pharmacotherapeutics. For the latter, human stem cell-based assays represent a physiologically relevant and high-throughput means to assess toxicity and other undesirable effects early in the drug development pipeline, avoiding late-stage attrition whilst expediting proof-of-concept of genuine drug candidates. Here we consider the potential of human embryonic, adult, and induced pluripotent stem cells for studying neurological disorders and preclinical drug development.

Publication Date


  • 2008

Citation


  • Crook, J. Micah. & Kobayashi, N. Rei. (2008). Human stem cells for modeling neurological disorders: accelerating the drug discovery pipeline. Journal of Cellular Biochemistry, 105 (6), 1361-1366.

Scopus Eid


  • 2-s2.0-57349129017

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1187

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 1361

End Page


  • 1366

Volume


  • 105

Issue


  • 6

Place Of Publication


  • United States