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G-protein coupled receptors in stem cell self-renewal and differentiation

Journal Article


Abstract


  • Stem cells have great potential for understanding early development, treating human disease, tissue trauma and early phase drug discovery. The factors that control the regulation of stem cell survival, proliferation, migration and differentiation are still emerging. Some evidence now exists demonstrating the potent effects of various G-protein coupled receptor (GPCR) ligands on the biology of stem cells. This review aims to give an overview of the current knowledge of the regulation of embryonic and somatic stem cell maintenance and differentiation by GPCR ligands.

Authors


  •   Kobayashi, Nao R. (external author)
  •   Hawes, Susan M. (external author)
  •   Crook, Jeremy M.
  •   Pebay, Alice (external author)

Publication Date


  • 2010

Citation


  • Kobayashi, N., Hawes, S. M., Crook, J. M. & Pebay, A. (2010). G-protein coupled receptors in stem cell self-renewal and differentiation. Stem Cell Reviews, 6 (3), 351-366.

Scopus Eid


  • 2-s2.0-77955848944

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1183

Has Global Citation Frequency


Number Of Pages


  • 15

Start Page


  • 351

End Page


  • 366

Volume


  • 6

Issue


  • 3

Place Of Publication


  • United States

Abstract


  • Stem cells have great potential for understanding early development, treating human disease, tissue trauma and early phase drug discovery. The factors that control the regulation of stem cell survival, proliferation, migration and differentiation are still emerging. Some evidence now exists demonstrating the potent effects of various G-protein coupled receptor (GPCR) ligands on the biology of stem cells. This review aims to give an overview of the current knowledge of the regulation of embryonic and somatic stem cell maintenance and differentiation by GPCR ligands.

Authors


  •   Kobayashi, Nao R. (external author)
  •   Hawes, Susan M. (external author)
  •   Crook, Jeremy M.
  •   Pebay, Alice (external author)

Publication Date


  • 2010

Citation


  • Kobayashi, N., Hawes, S. M., Crook, J. M. & Pebay, A. (2010). G-protein coupled receptors in stem cell self-renewal and differentiation. Stem Cell Reviews, 6 (3), 351-366.

Scopus Eid


  • 2-s2.0-77955848944

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1183

Has Global Citation Frequency


Number Of Pages


  • 15

Start Page


  • 351

End Page


  • 366

Volume


  • 6

Issue


  • 3

Place Of Publication


  • United States