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T Cells continue to play on the ATP circuit

Journal Article


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Abstract


  • The generation of immune responses involves the coordinated

    communication between cells through direct cell-to-cell contact

    and the release of various soluble factors binding to their respective

    receptors. Of the many soluble factors and receptors known, there

    is growing evidence that the release of extracellular adenosine

    triphosphate (ATP) and its subsequent activation of cell-surface

    ligand-gated cation channels belonging to the family of P2X receptors

    (P2X1-7) play important roles in communication between immune

    cells [1]. Much of what is understood about the roles of extracellular

    ATP and the activation of P2X receptors during an immune response

    has been inferred from in vitro studies requiring the addition of

    exogenous ATP or from studies using rodent models of inflammation

    and immunity [2]. Nevertheless our understanding of the extracellular

    ATP-P2X receptor axes operating between immune cells, including

    CD4+ T cells, during immune responses is limited.

Publication Date


  • 2014

Citation


  • Sluyter, R. & Watson, D. (2014). T Cells continue to play on the ATP circuit. Journal of Immune Research, 1 (1), 1-2.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3051&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2033

Number Of Pages


  • 1

Start Page


  • 1

End Page


  • 2

Volume


  • 1

Issue


  • 1

Place Of Publication


  • United States

Abstract


  • The generation of immune responses involves the coordinated

    communication between cells through direct cell-to-cell contact

    and the release of various soluble factors binding to their respective

    receptors. Of the many soluble factors and receptors known, there

    is growing evidence that the release of extracellular adenosine

    triphosphate (ATP) and its subsequent activation of cell-surface

    ligand-gated cation channels belonging to the family of P2X receptors

    (P2X1-7) play important roles in communication between immune

    cells [1]. Much of what is understood about the roles of extracellular

    ATP and the activation of P2X receptors during an immune response

    has been inferred from in vitro studies requiring the addition of

    exogenous ATP or from studies using rodent models of inflammation

    and immunity [2]. Nevertheless our understanding of the extracellular

    ATP-P2X receptor axes operating between immune cells, including

    CD4+ T cells, during immune responses is limited.

Publication Date


  • 2014

Citation


  • Sluyter, R. & Watson, D. (2014). T Cells continue to play on the ATP circuit. Journal of Immune Research, 1 (1), 1-2.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3051&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2033

Number Of Pages


  • 1

Start Page


  • 1

End Page


  • 2

Volume


  • 1

Issue


  • 1

Place Of Publication


  • United States