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Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile

Journal Article


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Abstract


  • With the objective of determining safety and verifying the traditional uses of the Bhutanese medicinal plant, Pleurospermum amabile Craib & W. W. Smith, we investigated its crude extracts and the isolated phytochemicals for their biological activities. Four phenylpropanoids [(E)-isomyristicin (1), (E)-isoapiol (2 ), methyl eugenol (3) and (E)-isoelemicin (4)] and six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8 ), oxypeucedanin hydrate (9) and oxypeucedanin methanolate (10 )] were isolated from this plant. Among the test samples, compound 10 showed weak antibacterial activity against Bacillus subtilis and best antimalarial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). None of the test samples showed cytotoxicity. This study generated scientific data that support the traditional medical uses of the plant.

Authors


  •   Wangchuk, Phurpa (external author)
  •   Pyne, Stephen G.
  •   Keller, Paul A.
  •   Taweechotipatr, Malai (external author)
  •   Kamchonwongpaisan, Sumalee (external author)

Publication Date


  • 2014

Citation


  • Wangchuk, P., Pyne, S. G., Keller, P. A., Taweechotipatr, M. & Kamchonwongpaisan, S. (2014). Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile. Natural Product Communications: an international journal for communications and reviews, 9 (7), 957-960.

Scopus Eid


  • 2-s2.0-84905105669

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3208&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2190

Number Of Pages


  • 3

Start Page


  • 957

End Page


  • 960

Volume


  • 9

Issue


  • 7

Abstract


  • With the objective of determining safety and verifying the traditional uses of the Bhutanese medicinal plant, Pleurospermum amabile Craib & W. W. Smith, we investigated its crude extracts and the isolated phytochemicals for their biological activities. Four phenylpropanoids [(E)-isomyristicin (1), (E)-isoapiol (2 ), methyl eugenol (3) and (E)-isoelemicin (4)] and six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8 ), oxypeucedanin hydrate (9) and oxypeucedanin methanolate (10 )] were isolated from this plant. Among the test samples, compound 10 showed weak antibacterial activity against Bacillus subtilis and best antimalarial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). None of the test samples showed cytotoxicity. This study generated scientific data that support the traditional medical uses of the plant.

Authors


  •   Wangchuk, Phurpa (external author)
  •   Pyne, Stephen G.
  •   Keller, Paul A.
  •   Taweechotipatr, Malai (external author)
  •   Kamchonwongpaisan, Sumalee (external author)

Publication Date


  • 2014

Citation


  • Wangchuk, P., Pyne, S. G., Keller, P. A., Taweechotipatr, M. & Kamchonwongpaisan, S. (2014). Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile. Natural Product Communications: an international journal for communications and reviews, 9 (7), 957-960.

Scopus Eid


  • 2-s2.0-84905105669

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3208&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2190

Number Of Pages


  • 3

Start Page


  • 957

End Page


  • 960

Volume


  • 9

Issue


  • 7