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Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice

Journal Article


Abstract


  • Rationale

    Patients suffering from Alzheimer’s disease (AD) exhibit a decline in cognitive abilities including an inability to recognise familiar faces. Hallmark pathological changes in AD include the aggregation of amyloid-β (Aβ), tau protein hyperphosphorylation as well as pronounced neurodegeneration, neuroinflammation, neurotoxicity and oxidative damage.

    Objectives

    The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, anti-oxidant and anti-inflammatory effects and promotes neurogenesis. CBD also reverses Aβ-induced spatial memory deficits in rodents.

    Materials and methods

    Thus we determined the therapeutic-like effects of chronic CBD treatment (20 mg/kg, daily intraperitoneal injections for 3 weeks) on the APPswe/PS1∆E9 (APPxPS1) transgenic mouse model for AD in a number of cognitive tests, including the social preference test, the novel object recognition task and the fear conditioning paradigm. We also analysed the impact of CBD on anxiety behaviours in the elevated plus maze.

    Results

    Vehicle-treated APPxPS1 mice demonstrated impairments in social recognition and novel object recognition compared to wild type-like mice. Chronic CBD treatment reversed these cognitive deficits in APPxPS1 mice without affecting anxiety-related behaviours.

    Conclusions

    This is the first study to investigate the effect of chronic CBD treatment on cognition in an AD transgenic mouse model. Our findings suggest that CBD may have therapeutic potential for specific cognitive impairments associated with AD.

Authors


  •   Cheng, David (external author)
  •   Low, Jac Kee. (external author)
  •   Logge, Warren (external author)
  •   Garner, Brett
  •   Karl, Tim (external author)

Publication Date


  • 2014

Citation


  • Cheng, D., Low, J. Kee., Logge, W., Garner, B. & Karl, T. (2014). Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice. Psychopharmacology, 231 (15), 3009-3017.

Scopus Eid


  • 2-s2.0-84904430556

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/450

Number Of Pages


  • 8

Start Page


  • 3009

End Page


  • 3017

Volume


  • 231

Issue


  • 15

Abstract


  • Rationale

    Patients suffering from Alzheimer’s disease (AD) exhibit a decline in cognitive abilities including an inability to recognise familiar faces. Hallmark pathological changes in AD include the aggregation of amyloid-β (Aβ), tau protein hyperphosphorylation as well as pronounced neurodegeneration, neuroinflammation, neurotoxicity and oxidative damage.

    Objectives

    The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, anti-oxidant and anti-inflammatory effects and promotes neurogenesis. CBD also reverses Aβ-induced spatial memory deficits in rodents.

    Materials and methods

    Thus we determined the therapeutic-like effects of chronic CBD treatment (20 mg/kg, daily intraperitoneal injections for 3 weeks) on the APPswe/PS1∆E9 (APPxPS1) transgenic mouse model for AD in a number of cognitive tests, including the social preference test, the novel object recognition task and the fear conditioning paradigm. We also analysed the impact of CBD on anxiety behaviours in the elevated plus maze.

    Results

    Vehicle-treated APPxPS1 mice demonstrated impairments in social recognition and novel object recognition compared to wild type-like mice. Chronic CBD treatment reversed these cognitive deficits in APPxPS1 mice without affecting anxiety-related behaviours.

    Conclusions

    This is the first study to investigate the effect of chronic CBD treatment on cognition in an AD transgenic mouse model. Our findings suggest that CBD may have therapeutic potential for specific cognitive impairments associated with AD.

Authors


  •   Cheng, David (external author)
  •   Low, Jac Kee. (external author)
  •   Logge, Warren (external author)
  •   Garner, Brett
  •   Karl, Tim (external author)

Publication Date


  • 2014

Citation


  • Cheng, D., Low, J. Kee., Logge, W., Garner, B. & Karl, T. (2014). Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice. Psychopharmacology, 231 (15), 3009-3017.

Scopus Eid


  • 2-s2.0-84904430556

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/450

Number Of Pages


  • 8

Start Page


  • 3009

End Page


  • 3017

Volume


  • 231

Issue


  • 15