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Recent advances in deep-sea natural products

Journal Article


Abstract


  • This review covers the 188 novel marine natural products described since 2008, from deep-water (50–>5000 m) marine fauna including bryozoa, chordata, cnidaria, echinodermata, microorganisms, mollusca and porifera. The structures of the new compounds and details of the source organism, depth of collection and country of origin are presented, along with any relevant biological activities of the metabolites. Where reported, synthetic studies on the deep-sea natural products have also been included. Most strikingly, 75% of the compounds were reported to possess bioactivity, with almost half exhibiting low micromolar cytotoxicity towards a range of human cancer cell lines, along with a significant increase in the number of microbial deep-sea natural products reported.

Publication Date


  • 2014

Citation


  • Skropeta, D. & Wei, L. (2014). Recent advances in deep-sea natural products. Natural Product Reports: a journal of current development in bioorganic chemistry, 31 (8), 999-1025.

Scopus Eid


  • 2-s2.0-84904163765

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2305

Number Of Pages


  • 26

Start Page


  • 999

End Page


  • 1025

Volume


  • 31

Issue


  • 8

Abstract


  • This review covers the 188 novel marine natural products described since 2008, from deep-water (50–>5000 m) marine fauna including bryozoa, chordata, cnidaria, echinodermata, microorganisms, mollusca and porifera. The structures of the new compounds and details of the source organism, depth of collection and country of origin are presented, along with any relevant biological activities of the metabolites. Where reported, synthetic studies on the deep-sea natural products have also been included. Most strikingly, 75% of the compounds were reported to possess bioactivity, with almost half exhibiting low micromolar cytotoxicity towards a range of human cancer cell lines, along with a significant increase in the number of microbial deep-sea natural products reported.

Publication Date


  • 2014

Citation


  • Skropeta, D. & Wei, L. (2014). Recent advances in deep-sea natural products. Natural Product Reports: a journal of current development in bioorganic chemistry, 31 (8), 999-1025.

Scopus Eid


  • 2-s2.0-84904163765

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2305

Number Of Pages


  • 26

Start Page


  • 999

End Page


  • 1025

Volume


  • 31

Issue


  • 8