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Emotion perception and electrophysiological correlates in Huntington’s disease

Journal Article


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Abstract


  • Objective

    This study aimed to characterise, emotion perception deficits in symptomatic Huntington’s disease (HD) via the use of event-related potentials (ERPs).

    Methods

    ERP data were recorded during a computerised facial expression task in 11 HD participants and 11 matched controls. Expression (scrambled, neutral, happy, angry, disgust) classification accuracy and intensity were assessed. Relationships between ERP indices and clinical disease characteristics were also examined.

    Results

    Accuracy was significantly lower for HD relative to controls, due to reduced performance for neutral, angry and disgust (but not happy) faces. Intensity ratings did not differ between groups. HD participants displayed significantly reduced visual processing amplitudes extending across pre-face (P100) and face-specific (N170) processing periods, whereas subsequent emotion processing amplitudes (N250) were similar across groups. Face-specific and emotion-specific derivations of the N170 and N250 (‘neutral minus scrambled’ and ‘each emotion minus neutral’, respectively) did not differ between groups.

    Conclusions

    Our data suggest that the facial emotion recognition performance deficits in HD are primarily related to neural degeneration underlying ‘generalised’ visual processing, rather than face or emotional specific processing.

    Significance

    ERPs are a useful tool to separate functionally discreet impairments in HD, and provide an important avenue for biomarker application that could more-selectively track disease progression.

Authors


  •   Croft, Rodney J.
  •   Mckernan, F (external author)
  •   Gray, M (external author)
  •   Churchyard, A (external author)
  •   Georgiou-Karistianis, Nellie (external author)

Publication Date


  • 2014

Citation


  • Croft, R. J., Mckernan, F., Gray, M., Churchyard, A. & Georgiou-Karistianis, N. (2014). Emotion perception and electrophysiological correlates in Huntington’s disease. Clinical Neurophysiology, 125 (8), 1618-1625.

Scopus Eid


  • 2-s2.0-84904055894

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1523&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/506

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1618

End Page


  • 1625

Volume


  • 125

Issue


  • 8

Place Of Publication


  • Ireland

Abstract


  • Objective

    This study aimed to characterise, emotion perception deficits in symptomatic Huntington’s disease (HD) via the use of event-related potentials (ERPs).

    Methods

    ERP data were recorded during a computerised facial expression task in 11 HD participants and 11 matched controls. Expression (scrambled, neutral, happy, angry, disgust) classification accuracy and intensity were assessed. Relationships between ERP indices and clinical disease characteristics were also examined.

    Results

    Accuracy was significantly lower for HD relative to controls, due to reduced performance for neutral, angry and disgust (but not happy) faces. Intensity ratings did not differ between groups. HD participants displayed significantly reduced visual processing amplitudes extending across pre-face (P100) and face-specific (N170) processing periods, whereas subsequent emotion processing amplitudes (N250) were similar across groups. Face-specific and emotion-specific derivations of the N170 and N250 (‘neutral minus scrambled’ and ‘each emotion minus neutral’, respectively) did not differ between groups.

    Conclusions

    Our data suggest that the facial emotion recognition performance deficits in HD are primarily related to neural degeneration underlying ‘generalised’ visual processing, rather than face or emotional specific processing.

    Significance

    ERPs are a useful tool to separate functionally discreet impairments in HD, and provide an important avenue for biomarker application that could more-selectively track disease progression.

Authors


  •   Croft, Rodney J.
  •   Mckernan, F (external author)
  •   Gray, M (external author)
  •   Churchyard, A (external author)
  •   Georgiou-Karistianis, Nellie (external author)

Publication Date


  • 2014

Citation


  • Croft, R. J., Mckernan, F., Gray, M., Churchyard, A. & Georgiou-Karistianis, N. (2014). Emotion perception and electrophysiological correlates in Huntington’s disease. Clinical Neurophysiology, 125 (8), 1618-1625.

Scopus Eid


  • 2-s2.0-84904055894

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1523&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/506

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1618

End Page


  • 1625

Volume


  • 125

Issue


  • 8

Place Of Publication


  • Ireland