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Anion formation in gas-phase potassium-uridine collisions

Journal Article


Abstract


  • In this study we report negative ion fragmentation patterns obtained from time-of-flight (TOF) mass spectrometry in potassium-uridine collisions at 30, 70 and 100 eV. The dominant fragments from uridine are also the most abundant from the individual units in potassium collisions with uracil, tetrahydrofuran (THF) and d-ribose. We observe no dehydrogenated parent anion formation. Special emphasis is given to the dissociation mechanisms lending support to the breaking of the N-glycosidic bond as an initial step in the fragmentation of the transient negative ion (TNI). Within their role as sugar unit surrogates, THF and d-ribose (DR) provide useful information for the study of uridine, and presumably other nucleosides from the point of view of DNA/RNA subunits integrity in the biological environment.

UOW Authors


  •   Almeida, Diego T. (external author)
  •   Da Silva, F. Ferreira (external author)
  •   Limao-Vieira, Paulo (external author)
  •   Kopyra, Janina (external author)
  •   Garcia, Gustavo

Publication Date


  • 2014

Citation


  • Almeida, D., da Silva, F., Kopyra, J., Garcia, G. & Limao-Vieira, P. (2014). Anion formation in gas-phase potassium-uridine collisions. International Journal of Mass Spectrometry, 365-366 243-247.

Scopus Eid


  • 2-s2.0-84901917320

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/2827

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 243

End Page


  • 247

Volume


  • 365-366

Abstract


  • In this study we report negative ion fragmentation patterns obtained from time-of-flight (TOF) mass spectrometry in potassium-uridine collisions at 30, 70 and 100 eV. The dominant fragments from uridine are also the most abundant from the individual units in potassium collisions with uracil, tetrahydrofuran (THF) and d-ribose. We observe no dehydrogenated parent anion formation. Special emphasis is given to the dissociation mechanisms lending support to the breaking of the N-glycosidic bond as an initial step in the fragmentation of the transient negative ion (TNI). Within their role as sugar unit surrogates, THF and d-ribose (DR) provide useful information for the study of uridine, and presumably other nucleosides from the point of view of DNA/RNA subunits integrity in the biological environment.

UOW Authors


  •   Almeida, Diego T. (external author)
  •   Da Silva, F. Ferreira (external author)
  •   Limao-Vieira, Paulo (external author)
  •   Kopyra, Janina (external author)
  •   Garcia, Gustavo

Publication Date


  • 2014

Citation


  • Almeida, D., da Silva, F., Kopyra, J., Garcia, G. & Limao-Vieira, P. (2014). Anion formation in gas-phase potassium-uridine collisions. International Journal of Mass Spectrometry, 365-366 243-247.

Scopus Eid


  • 2-s2.0-84901917320

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/2827

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 243

End Page


  • 247

Volume


  • 365-366