The variation of the shear strength of infilled rock joints under cyclic loading and constant normal stiffness conditions is studied. To simulate the joints, triangular asperities inclined at angles of 9.5° and 18.5° to the shear movement were cast using high-strength gypsum plaster and infilled with clayey sand. These joints were sheared cyclically under constant normal stiffness conditions. It was found that, for a particular normal stiffness, the shear strength is a function of the initial normal stress, initial asperity angle, joint surface friction angle, infill thickness, infill friction angle, loading direction and number of loading cycles. Based on the experimental results, a mathematical model is proposed to evaluate the shear strength of infilled rock joints in cyclic loading conditions. The proposed model takes into consideration different initial asperity angles, initial normal stresses and ratios of infill thickness to asperity height.