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On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser

Journal Article


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Abstract


  • This paper proposes a novel concept of dielectrophoresis (DEP)-active hydrophoretic focusing of

    micro-particles and murine erythroleukemia (MEL) cells. The DEP-active hydrophoretic platform consists

    of crescent shaped grooves and interdigitated electrodes that generate lateral pressure gradients. These

    embedded electrodes exert a negative DEP force onto the particles by pushing them into a narrow space in

    the channel where the particle to groove interaction is intensive and hydrophoretic ordering occurs.

    Particles passing through the microfluidic device are directed towards the sidewalls of the channel. The

    critical limitation of DEP operating at a low flow rate and the specific hydrophoretic device for focusing

    particles of given sizes were overcome with the proposed microfluidic device. The focusing pattern can be

    modulated by varying the voltage. High throughput was achieved (maximum flow rate ,150 mL min21)

    with good focusing performance. The non-spherical MEL cells were utilised to verify the effectiveness of the

    DEP-active hydrophoretic device.

Publication Date


  • 2014

Citation


  • Yan, S., Zhang, J., Li, M., Alici, G., Du, H., Sluyter, R. & Li, W. (2014). On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser. Scientific Reports, 4 1-8.

Scopus Eid


  • 2-s2.0-84901508653

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3443&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/2434

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1

End Page


  • 8

Volume


  • 4

Place Of Publication


  • United Kingdom

Abstract


  • This paper proposes a novel concept of dielectrophoresis (DEP)-active hydrophoretic focusing of

    micro-particles and murine erythroleukemia (MEL) cells. The DEP-active hydrophoretic platform consists

    of crescent shaped grooves and interdigitated electrodes that generate lateral pressure gradients. These

    embedded electrodes exert a negative DEP force onto the particles by pushing them into a narrow space in

    the channel where the particle to groove interaction is intensive and hydrophoretic ordering occurs.

    Particles passing through the microfluidic device are directed towards the sidewalls of the channel. The

    critical limitation of DEP operating at a low flow rate and the specific hydrophoretic device for focusing

    particles of given sizes were overcome with the proposed microfluidic device. The focusing pattern can be

    modulated by varying the voltage. High throughput was achieved (maximum flow rate ,150 mL min21)

    with good focusing performance. The non-spherical MEL cells were utilised to verify the effectiveness of the

    DEP-active hydrophoretic device.

Publication Date


  • 2014

Citation


  • Yan, S., Zhang, J., Li, M., Alici, G., Du, H., Sluyter, R. & Li, W. (2014). On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser. Scientific Reports, 4 1-8.

Scopus Eid


  • 2-s2.0-84901508653

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3443&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/2434

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1

End Page


  • 8

Volume


  • 4

Place Of Publication


  • United Kingdom