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Recent advances in nerve tissue engineering

Journal Article


Abstract


  • Nerve injury secondary to trauma, neurological disease or tumor excision presents a challenge for

    surgical reconstruction. Current practice for nerve repair involves autologous nerve transplantation,

    which is associated with significant donor-site morbidity and other complications. Previously artificial

    nerve conduits made from polycaprolactone, polyglycolic acid and collagen were approved by the

    FDA (USA) for nerve repair. More recently, there have been significant advances in nerve conduit design

    that better address the requirements of nerve regrowth. Innovations in materials science, nanotechnology,

    and biology open the way for the synthesis of new generation nerve repair conduits that

    address issues currently faced in nerve repair and regeneration. This review discusses recent innovations

    in this area, including the use of nanotechnology to improve the design of nerve conduits and to

    enhance nerve regeneration.

Publication Date


  • 2014

Citation


  • Zhang, B. G. X., Quigley, A. F., Myers, D. E., Wallace, G. G., Kapsa, R. & Choong, P. F. M. (2014). Recent advances in nerve tissue engineering. International Journal of Artificial Organs, 37 (4), 277-291.

Scopus Eid


  • 2-s2.0-84900404479

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1079

Has Global Citation Frequency


Number Of Pages


  • 14

Start Page


  • 277

End Page


  • 291

Volume


  • 37

Issue


  • 4

Place Of Publication


  • Italy

Abstract


  • Nerve injury secondary to trauma, neurological disease or tumor excision presents a challenge for

    surgical reconstruction. Current practice for nerve repair involves autologous nerve transplantation,

    which is associated with significant donor-site morbidity and other complications. Previously artificial

    nerve conduits made from polycaprolactone, polyglycolic acid and collagen were approved by the

    FDA (USA) for nerve repair. More recently, there have been significant advances in nerve conduit design

    that better address the requirements of nerve regrowth. Innovations in materials science, nanotechnology,

    and biology open the way for the synthesis of new generation nerve repair conduits that

    address issues currently faced in nerve repair and regeneration. This review discusses recent innovations

    in this area, including the use of nanotechnology to improve the design of nerve conduits and to

    enhance nerve regeneration.

Publication Date


  • 2014

Citation


  • Zhang, B. G. X., Quigley, A. F., Myers, D. E., Wallace, G. G., Kapsa, R. & Choong, P. F. M. (2014). Recent advances in nerve tissue engineering. International Journal of Artificial Organs, 37 (4), 277-291.

Scopus Eid


  • 2-s2.0-84900404479

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1079

Has Global Citation Frequency


Number Of Pages


  • 14

Start Page


  • 277

End Page


  • 291

Volume


  • 37

Issue


  • 4

Place Of Publication


  • Italy