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Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities

Journal Article


Abstract


  • Four new stichoneurine-type alkaloids, stichoneurines F and G (1–2) and sessilistemonamines E and F (3–4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1–4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1 ± 0.15 μM.

Publication Date


  • 2014

Citation


  • Ramli, R. A., Lie, W. & Pyne, S. G. (2014). Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities. Journal of Natural Products, 77 (4), 894-901.

Scopus Eid


  • 2-s2.0-84899546430

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1925

Number Of Pages


  • 7

Start Page


  • 894

End Page


  • 901

Volume


  • 77

Issue


  • 4

Abstract


  • Four new stichoneurine-type alkaloids, stichoneurines F and G (1–2) and sessilistemonamines E and F (3–4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1–4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1 ± 0.15 μM.

Publication Date


  • 2014

Citation


  • Ramli, R. A., Lie, W. & Pyne, S. G. (2014). Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities. Journal of Natural Products, 77 (4), 894-901.

Scopus Eid


  • 2-s2.0-84899546430

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1925

Number Of Pages


  • 7

Start Page


  • 894

End Page


  • 901

Volume


  • 77

Issue


  • 4