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Membrane fatty acid composition and longevity of mammals and birds

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Abstract


  • The fatty acid composition of membrane lipids varies

    systematically among species in a manner that is consistent with their

    metabolic rate and longevity. Because the susceptibility of fatty acids

    to peroxidation relates directly to their extent of unsaturation, it is

    possible to calculate a peroxidation index (PI) for membranes

    through characterization of their specific fatty acid composition.

    Long-living mammals and birds have membrane lipids with a lower

    PI than shorter-living species. Bird and mammal species with the

    same maximum life span also have membrane lipids with essentially

    the same PI. Exceptionally long-living mammals and birds usually

    have membrane lipids high in monounsaturates, but low in

    polyunsaturates, with the consequence that the PI of their membrane

    lipids is as low as expected for their respective longevity. Longevity

    variation within species (whether due to calorie-restriction, extended

    longevity associated with specific strains, queen-worker differences

    in honey bees or inherited longevity differences among humans) is

    also associated with differences in membrane composition and PI.

    Membrane composition is specific for each species and PI appears to

    generally be resistant to dietary manipulation. It is postulated that

    membrane fatty acid composition is an important influence on aging

    and the determination of maximum life span.

Publication Date


  • 2010

Citation


  • Hulbert, A. J., Trzcionka, M. & Buttemer, W. A. (2010). Membrane fatty acid composition and longevity of mammals and birds. In R. Pamplona & G. Barja (Eds.), Longevity, Mitochondria and Oxygen Free Radicals (pp. 79-93). Kerala, India: Research Signpost.

International Standard Book Number (isbn) 13


  • 9788130804156

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2832&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1814

Book Title


  • Longevity, Mitochondria and Oxygen Free Radicals

Start Page


  • 79

End Page


  • 93

Place Of Publication


  • Kerala, India

Abstract


  • The fatty acid composition of membrane lipids varies

    systematically among species in a manner that is consistent with their

    metabolic rate and longevity. Because the susceptibility of fatty acids

    to peroxidation relates directly to their extent of unsaturation, it is

    possible to calculate a peroxidation index (PI) for membranes

    through characterization of their specific fatty acid composition.

    Long-living mammals and birds have membrane lipids with a lower

    PI than shorter-living species. Bird and mammal species with the

    same maximum life span also have membrane lipids with essentially

    the same PI. Exceptionally long-living mammals and birds usually

    have membrane lipids high in monounsaturates, but low in

    polyunsaturates, with the consequence that the PI of their membrane

    lipids is as low as expected for their respective longevity. Longevity

    variation within species (whether due to calorie-restriction, extended

    longevity associated with specific strains, queen-worker differences

    in honey bees or inherited longevity differences among humans) is

    also associated with differences in membrane composition and PI.

    Membrane composition is specific for each species and PI appears to

    generally be resistant to dietary manipulation. It is postulated that

    membrane fatty acid composition is an important influence on aging

    and the determination of maximum life span.

Publication Date


  • 2010

Citation


  • Hulbert, A. J., Trzcionka, M. & Buttemer, W. A. (2010). Membrane fatty acid composition and longevity of mammals and birds. In R. Pamplona & G. Barja (Eds.), Longevity, Mitochondria and Oxygen Free Radicals (pp. 79-93). Kerala, India: Research Signpost.

International Standard Book Number (isbn) 13


  • 9788130804156

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2832&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1814

Book Title


  • Longevity, Mitochondria and Oxygen Free Radicals

Start Page


  • 79

End Page


  • 93

Place Of Publication


  • Kerala, India