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Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats

Journal Article


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Abstract


  • Excessive weight gain is a major metabolic side effect of second-generation antipsychotics (SGAs) in the treatment of schizophrenia. Ghrelin is an orexigenic hormone secreted mainly from the stomach, which can induce weight gain and hyperphagia through regulating neuropeptides at the hypothalamus. Accumulating evidence implicates a relationship between ghrelin signalling and SGA-induced hyperphagia and weight gain. We report that olanzapine (a SGA with high weight gain liability) potently and time-dependently up-regulate ghrelin and ghrelin signalling, leading to hyperphagia and weight gain in female Sprague-Dawley rats, an action reversed by i.c.v. injection of a ghrelin receptor (GHS-R1a) antagonist. These findings indicate a crucial role of ghrelin signalling in hyperphagia induced by olanzapine, supporting the notion that GHS-R1a antagonist may be useful for pharmacological treatment of SGA-induced weight gain resulted from hyperphagia.

Publication Date


  • 2014

Citation


  • Zhang, Q., He, M., Deng, C., Wang, H., Lian, J. & Huang, X. (2014). Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats. International Journal of Neuropsychopharmacology, 17 (5), 807-818.

Scopus Eid


  • 2-s2.0-84895759139

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1433&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/416

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 807

End Page


  • 818

Volume


  • 17

Issue


  • 5

Place Of Publication


  • United Kingdom

Abstract


  • Excessive weight gain is a major metabolic side effect of second-generation antipsychotics (SGAs) in the treatment of schizophrenia. Ghrelin is an orexigenic hormone secreted mainly from the stomach, which can induce weight gain and hyperphagia through regulating neuropeptides at the hypothalamus. Accumulating evidence implicates a relationship between ghrelin signalling and SGA-induced hyperphagia and weight gain. We report that olanzapine (a SGA with high weight gain liability) potently and time-dependently up-regulate ghrelin and ghrelin signalling, leading to hyperphagia and weight gain in female Sprague-Dawley rats, an action reversed by i.c.v. injection of a ghrelin receptor (GHS-R1a) antagonist. These findings indicate a crucial role of ghrelin signalling in hyperphagia induced by olanzapine, supporting the notion that GHS-R1a antagonist may be useful for pharmacological treatment of SGA-induced weight gain resulted from hyperphagia.

Publication Date


  • 2014

Citation


  • Zhang, Q., He, M., Deng, C., Wang, H., Lian, J. & Huang, X. (2014). Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats. International Journal of Neuropsychopharmacology, 17 (5), 807-818.

Scopus Eid


  • 2-s2.0-84895759139

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1433&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/416

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 807

End Page


  • 818

Volume


  • 17

Issue


  • 5

Place Of Publication


  • United Kingdom