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Regional differences in trait-like characteristics of the waking EEG in early adolescence

Journal Article


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Abstract


  • Background: The human waking EEG spectrum shows high heritability and stability and, despite maturational

    cortical changes, high test-retest reliability in children and teens. These phenomena have also been shown to be

    region specific. We examined the stability of the morphology of the wake EEG spectrum in children aged 11 to 13

    years recorded over weekly intervals and assessed whether the waking EEG spectrum in children may also be traitlike.

    Three minutes of eyes open and three minutes of eyes closed waking EEG was recorded in 22 healthy children

    once a week for three consecutive weeks. Eyes open and closed EEG power density spectra were calculated for two

    central (C3LM and C4LM) and two occipital (O1LM and O2LM) derivations. A hierarchical cluster analysis was

    performed to determine whether the morphology of the waking EEG spectrum between 1 and 20 Hz is trait-like.

    We also examined the stability of the alpha peak using an ANOVA.

    Results: The morphology of the EEG spectrum recorded from central derivations was highly stable and unique to

    an individual (correctly classified in 85% of participants), while the EEG recorded from occipital derivations, while

    stable, was much less unique across individuals (correctly classified in 42% of participants). Furthermore, our analysis

    revealed an increase in alpha peak height concurrent with a decline in the frequency of the alpha peak across

    weeks for occipital derivations. No changes in either measure were observed in the central derivations.

    Conclusions: Our results indicate that across weekly recordings, power spectra at central derivations exhibit more

    “trait-like” characteristics than occipital derivations. These results may be relevant for future studies searching for

    links between phenotypes, such as psychiatric diagnoses, and the underlying genes (i.e., endophenotypes) by

    suggesting that such studies should make use of more anterior rather than posterior EEG derivations.

Authors


  •   Benz, Dominik C. (external author)
  •   Tarokh, Leila (external author)
  •   Achermann, Peter (external author)
  •   Loughran, Sarah P. (external author)

Publication Date


  • 2013

Citation


  • Benz, D. C., Tarokh, L., Achermann, P. & Loughran, S. P. (2013). Regional differences in trait-like characteristics of the waking EEG in early adolescence. BMC Neuroscience, 14 (117), 1-8.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1624&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/625

Number Of Pages


  • 7

Start Page


  • 1

End Page


  • 8

Volume


  • 14

Issue


  • 117

Abstract


  • Background: The human waking EEG spectrum shows high heritability and stability and, despite maturational

    cortical changes, high test-retest reliability in children and teens. These phenomena have also been shown to be

    region specific. We examined the stability of the morphology of the wake EEG spectrum in children aged 11 to 13

    years recorded over weekly intervals and assessed whether the waking EEG spectrum in children may also be traitlike.

    Three minutes of eyes open and three minutes of eyes closed waking EEG was recorded in 22 healthy children

    once a week for three consecutive weeks. Eyes open and closed EEG power density spectra were calculated for two

    central (C3LM and C4LM) and two occipital (O1LM and O2LM) derivations. A hierarchical cluster analysis was

    performed to determine whether the morphology of the waking EEG spectrum between 1 and 20 Hz is trait-like.

    We also examined the stability of the alpha peak using an ANOVA.

    Results: The morphology of the EEG spectrum recorded from central derivations was highly stable and unique to

    an individual (correctly classified in 85% of participants), while the EEG recorded from occipital derivations, while

    stable, was much less unique across individuals (correctly classified in 42% of participants). Furthermore, our analysis

    revealed an increase in alpha peak height concurrent with a decline in the frequency of the alpha peak across

    weeks for occipital derivations. No changes in either measure were observed in the central derivations.

    Conclusions: Our results indicate that across weekly recordings, power spectra at central derivations exhibit more

    “trait-like” characteristics than occipital derivations. These results may be relevant for future studies searching for

    links between phenotypes, such as psychiatric diagnoses, and the underlying genes (i.e., endophenotypes) by

    suggesting that such studies should make use of more anterior rather than posterior EEG derivations.

Authors


  •   Benz, Dominik C. (external author)
  •   Tarokh, Leila (external author)
  •   Achermann, Peter (external author)
  •   Loughran, Sarah P. (external author)

Publication Date


  • 2013

Citation


  • Benz, D. C., Tarokh, L., Achermann, P. & Loughran, S. P. (2013). Regional differences in trait-like characteristics of the waking EEG in early adolescence. BMC Neuroscience, 14 (117), 1-8.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1624&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/625

Number Of Pages


  • 7

Start Page


  • 1

End Page


  • 8

Volume


  • 14

Issue


  • 117