Background: The human waking EEG spectrum shows high heritability and stability and, despite maturational
cortical changes, high test-retest reliability in children and teens. These phenomena have also been shown to be
region specific. We examined the stability of the morphology of the wake EEG spectrum in children aged 11 to 13
years recorded over weekly intervals and assessed whether the waking EEG spectrum in children may also be traitlike.
Three minutes of eyes open and three minutes of eyes closed waking EEG was recorded in 22 healthy children
once a week for three consecutive weeks. Eyes open and closed EEG power density spectra were calculated for two
central (C3LM and C4LM) and two occipital (O1LM and O2LM) derivations. A hierarchical cluster analysis was
performed to determine whether the morphology of the waking EEG spectrum between 1 and 20 Hz is trait-like.
We also examined the stability of the alpha peak using an ANOVA.
Results: The morphology of the EEG spectrum recorded from central derivations was highly stable and unique to
an individual (correctly classified in 85% of participants), while the EEG recorded from occipital derivations, while
stable, was much less unique across individuals (correctly classified in 42% of participants). Furthermore, our analysis
revealed an increase in alpha peak height concurrent with a decline in the frequency of the alpha peak across
weeks for occipital derivations. No changes in either measure were observed in the central derivations.
Conclusions: Our results indicate that across weekly recordings, power spectra at central derivations exhibit more
“trait-like” characteristics than occipital derivations. These results may be relevant for future studies searching for
links between phenotypes, such as psychiatric diagnoses, and the underlying genes (i.e., endophenotypes) by
suggesting that such studies should make use of more anterior rather than posterior EEG derivations.