Skip to main content
placeholder image

Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease

Journal Article


Download full-text (Open Access)

Abstract


  • Chronic kidney disease (CKD) is a major cause of death and morbidity in Australia and worldwide. DNA vaccination has been used for targeting foreign antigens to induce immune responses and prevent autoimmune disease, viral infection and cancer. However, the use of DNA vaccination has been restricted by a limited ability to induce strong immune responses, especially against self-antigens which are limited by mechanisms of self-tolerance. Furthermore, there have been few studies on the potential of DNA vaccination in chronic inflammatory diseases, including CKD. We have established strategies of DNA vaccination targeting specific self-antigens in the immune system including co-stimulatory pathways, T cell receptors and chemokine molecules, which have been effective in protecting against the development of CKD in a variety of animal models. In particular, we find that the efficacy of DNA vaccination is improved by dendritic cell (DC) targeting and can protect against animal models of autoimmune nephritis mimicking human membranous nephropathy. In this review, we summarize several approaches that have been tested to improve the efficacy of DNA vaccination in CKD models, including enhanced DNA vaccine delivery methods, DNA vaccine modifications and new molecular targets for DNA vaccination. Finally, we discuss the specific application of DNA vaccination for preventing and treating CKD.

Authors


  •   Wang, Yuan-Min (external author)
  •   Zhou, Jimmy Jianheng (external author)
  •   Wang, Ya (external author)
  •   Watson, Debbie
  •   Zhang, Geoff Yu. (external author)
  •   Hu, Min (external author)
  •   Wu, Huiling (external author)
  •   Wang, Yiping (external author)
  •   Durkan, Anne M. (external author)
  •   Harris, David C. (external author)
  •   Alexander, Stephen I. (external author)

Publication Date


  • 2013

Citation


  • Wang, Y. Min., Zhou, J., Wang, Y., Watson, D., Zhang, G. Yu., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A. M., Harris, D. CH. & Alexander, S. I. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6 (3), 326-333.

Scopus Eid


  • 2-s2.0-84881506590

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2297&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1279

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 326

End Page


  • 333

Volume


  • 6

Issue


  • 3

Place Of Publication


  • United States

Abstract


  • Chronic kidney disease (CKD) is a major cause of death and morbidity in Australia and worldwide. DNA vaccination has been used for targeting foreign antigens to induce immune responses and prevent autoimmune disease, viral infection and cancer. However, the use of DNA vaccination has been restricted by a limited ability to induce strong immune responses, especially against self-antigens which are limited by mechanisms of self-tolerance. Furthermore, there have been few studies on the potential of DNA vaccination in chronic inflammatory diseases, including CKD. We have established strategies of DNA vaccination targeting specific self-antigens in the immune system including co-stimulatory pathways, T cell receptors and chemokine molecules, which have been effective in protecting against the development of CKD in a variety of animal models. In particular, we find that the efficacy of DNA vaccination is improved by dendritic cell (DC) targeting and can protect against animal models of autoimmune nephritis mimicking human membranous nephropathy. In this review, we summarize several approaches that have been tested to improve the efficacy of DNA vaccination in CKD models, including enhanced DNA vaccine delivery methods, DNA vaccine modifications and new molecular targets for DNA vaccination. Finally, we discuss the specific application of DNA vaccination for preventing and treating CKD.

Authors


  •   Wang, Yuan-Min (external author)
  •   Zhou, Jimmy Jianheng (external author)
  •   Wang, Ya (external author)
  •   Watson, Debbie
  •   Zhang, Geoff Yu. (external author)
  •   Hu, Min (external author)
  •   Wu, Huiling (external author)
  •   Wang, Yiping (external author)
  •   Durkan, Anne M. (external author)
  •   Harris, David C. (external author)
  •   Alexander, Stephen I. (external author)

Publication Date


  • 2013

Citation


  • Wang, Y. Min., Zhou, J., Wang, Y., Watson, D., Zhang, G. Yu., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A. M., Harris, D. CH. & Alexander, S. I. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6 (3), 326-333.

Scopus Eid


  • 2-s2.0-84881506590

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2297&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1279

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 326

End Page


  • 333

Volume


  • 6

Issue


  • 3

Place Of Publication


  • United States