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Modelling carbon dioxide molecule interacting with aquaglyceroporin and aquaporin-1 channels

Journal Article


Abstract


  • Aquaporin (AQP) is a family of membrane proteins that enable water and small individual molecules to permeate cell membranes. Examples of these protein channels are aquaglyceroporin and aquaporin-1 (AQP1). Here, we investigate the permeability of carbon dioxide (CO2) through both aquglyceroporin and AQP1 channels and explain their selectivity mechanisms. We provide a mathematical model which determines the molecular interaction potential between carbon dioxide molecule and an AQP channel. We evaluate this interaction using two approaches, namely discrete-continuum and completed discrete approaches. Both calculations agree well and our results indicate the acceptance of (CO2) molecule into these channels which is in good agreement with other recent studies. © 2013 Springer Science+Business Media New York.

UOW Authors


  •   Al Garalleh, Hakim Abdul (external author)
  •   Thamwattana, Natalie
  •   Cox, Barry J. (external author)
  •   Hill, James (external author)

Publication Date


  • 2013

Citation


  • Al Garalleh, H., Thamwattana, N., Cox, B. J. & Hill, J. (2013). Modelling carbon dioxide molecule interacting with aquaglyceroporin and aquaporin-1 channels. Journal of Mathematical Chemistry, 51 (9), 2317-2327.

Scopus Eid


  • 2-s2.0-84883773269

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/1327

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 2317

End Page


  • 2327

Volume


  • 51

Issue


  • 9

Place Of Publication


  • Netherlands

Abstract


  • Aquaporin (AQP) is a family of membrane proteins that enable water and small individual molecules to permeate cell membranes. Examples of these protein channels are aquaglyceroporin and aquaporin-1 (AQP1). Here, we investigate the permeability of carbon dioxide (CO2) through both aquglyceroporin and AQP1 channels and explain their selectivity mechanisms. We provide a mathematical model which determines the molecular interaction potential between carbon dioxide molecule and an AQP channel. We evaluate this interaction using two approaches, namely discrete-continuum and completed discrete approaches. Both calculations agree well and our results indicate the acceptance of (CO2) molecule into these channels which is in good agreement with other recent studies. © 2013 Springer Science+Business Media New York.

UOW Authors


  •   Al Garalleh, Hakim Abdul (external author)
  •   Thamwattana, Natalie
  •   Cox, Barry J. (external author)
  •   Hill, James (external author)

Publication Date


  • 2013

Citation


  • Al Garalleh, H., Thamwattana, N., Cox, B. J. & Hill, J. (2013). Modelling carbon dioxide molecule interacting with aquaglyceroporin and aquaporin-1 channels. Journal of Mathematical Chemistry, 51 (9), 2317-2327.

Scopus Eid


  • 2-s2.0-84883773269

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/1327

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 2317

End Page


  • 2327

Volume


  • 51

Issue


  • 9

Place Of Publication


  • Netherlands