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Effects of antipsychotic medications on appetite, weight, and insulin resistance

Journal Article


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Abstract


  • Although clozapine, olanzapine, and other atypical antipsychotic drugs (APDs) have fewer extrapyramidal side effects, they have serious metabolic side effects such as substantial weight gain, intra-abdominal obesity, and type 2 diabetes mellitus. Given that most patients with mental disorders face chronic, even life-long, treatment with APDs, the risks of weight gain/obesity and other metabolic symptoms are major considerations for APD maintenance treatment. This review focuses on the effects of APDs on weight gain, appetite, insulin resistance, and glucose dysregulation, and the relevant underlying mechanisms that may be help to prevent and treat metabolic side effects caused by APD therapy.

Publication Date


  • 2013

Citation


  • Deng, C. (2013). Effects of antipsychotic medications on appetite, weight, and insulin resistance. Endocrinology and Metabolism Clinics of North America, 42 (3), 545-563.

Scopus Eid


  • 2-s2.0-84883504978

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1371&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/354

Has Global Citation Frequency


Number Of Pages


  • 18

Start Page


  • 545

End Page


  • 563

Volume


  • 42

Issue


  • 3

Place Of Publication


  • United States

Abstract


  • Although clozapine, olanzapine, and other atypical antipsychotic drugs (APDs) have fewer extrapyramidal side effects, they have serious metabolic side effects such as substantial weight gain, intra-abdominal obesity, and type 2 diabetes mellitus. Given that most patients with mental disorders face chronic, even life-long, treatment with APDs, the risks of weight gain/obesity and other metabolic symptoms are major considerations for APD maintenance treatment. This review focuses on the effects of APDs on weight gain, appetite, insulin resistance, and glucose dysregulation, and the relevant underlying mechanisms that may be help to prevent and treat metabolic side effects caused by APD therapy.

Publication Date


  • 2013

Citation


  • Deng, C. (2013). Effects of antipsychotic medications on appetite, weight, and insulin resistance. Endocrinology and Metabolism Clinics of North America, 42 (3), 545-563.

Scopus Eid


  • 2-s2.0-84883504978

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1371&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/354

Has Global Citation Frequency


Number Of Pages


  • 18

Start Page


  • 545

End Page


  • 563

Volume


  • 42

Issue


  • 3

Place Of Publication


  • United States