Extrusion printing of ionic-covalent entanglement hydrogels with high toughness

Journal Article


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Abstract


  • Three-dimensional (3D) printing of hydrogels has recently been investigated for use in tissue engineering

    applications. One major limitation in the use of synthetic hydrogels is their poor mechanical robustness but

    the development of ‘tough hydrogels’ in conjunction with additive fabrication techniques will accelerate

    the advancement of many technologies including soft robotics, bionic implants, sensors and controlled

    release systems. This article demonstrates that ionic–covalent entanglement (ICE) gels can be fabricated

    through a modified extrusion printing process that facilitates in situ photopolymerisation. The

    rheological properties of alginate–acrylamide hydrogel precursor solutions were characterised to

    develop formulations suitable for extrusion printing. A range of these printed hydrogels were prepared

    and their mechanical performance and swelling behaviour evaluated. ICE gels exhibit a remarkable

    mechanical performance because ionic cross links in the biopolymer network act as sacrificial bonds that

    dissipate energy under stress. The printed ICE gels have a work of extension 260 3 kj m3. Swelling

    the hydrogels in water has a detrimental effect upon their mechanical properties, however swelling the

    hydrogels in a calcium chloride solution as a post-processing technique reduces the effects of swelling

    the hydrogels in water. The integration of the modified extrusion printing process with existing plastic

    3D printing technologies will allow for the fabrication of functional devices.

Publication Date


  • 2013

Citation


  • Bakarich, S. E., in het Panhuis, M., Beirne, S., Wallace, G. G. & Spinks, G. M. (2013). Extrusion printing of ionic-covalent entanglement hydrogels with high toughness. Journal of Materials Chemistry B, 1 (38), 4939-4946.

Scopus Eid


  • 2-s2.0-84883859145

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1856&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/855

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 4939

End Page


  • 4946

Volume


  • 1

Issue


  • 38

Place Of Publication


  • United Kingdom

Abstract


  • Three-dimensional (3D) printing of hydrogels has recently been investigated for use in tissue engineering

    applications. One major limitation in the use of synthetic hydrogels is their poor mechanical robustness but

    the development of ‘tough hydrogels’ in conjunction with additive fabrication techniques will accelerate

    the advancement of many technologies including soft robotics, bionic implants, sensors and controlled

    release systems. This article demonstrates that ionic–covalent entanglement (ICE) gels can be fabricated

    through a modified extrusion printing process that facilitates in situ photopolymerisation. The

    rheological properties of alginate–acrylamide hydrogel precursor solutions were characterised to

    develop formulations suitable for extrusion printing. A range of these printed hydrogels were prepared

    and their mechanical performance and swelling behaviour evaluated. ICE gels exhibit a remarkable

    mechanical performance because ionic cross links in the biopolymer network act as sacrificial bonds that

    dissipate energy under stress. The printed ICE gels have a work of extension 260 3 kj m3. Swelling

    the hydrogels in water has a detrimental effect upon their mechanical properties, however swelling the

    hydrogels in a calcium chloride solution as a post-processing technique reduces the effects of swelling

    the hydrogels in water. The integration of the modified extrusion printing process with existing plastic

    3D printing technologies will allow for the fabrication of functional devices.

Publication Date


  • 2013

Citation


  • Bakarich, S. E., in het Panhuis, M., Beirne, S., Wallace, G. G. & Spinks, G. M. (2013). Extrusion printing of ionic-covalent entanglement hydrogels with high toughness. Journal of Materials Chemistry B, 1 (38), 4939-4946.

Scopus Eid


  • 2-s2.0-84883859145

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1856&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/855

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 4939

End Page


  • 4946

Volume


  • 1

Issue


  • 38

Place Of Publication


  • United Kingdom