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Investigation of trapping process in “Centrifuge-on-a-chip”

Conference Paper


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Abstract


  • “Centrifuge-on-a-chip” is a versatile and

    multifunctional microfluidic chip which can conduct

    operations of selective trapping, enrichment, labeling and

    solution exchange. In this work, the mechanism of selective

    trapping ability was studied by both the experiments and

    numerical simulation. We proved the existence of shear

    gradient lift force in the expansion-contraction cavity and

    derived an explicit expression of it. Also, a numerical

    modeling was developed to study the trapping process of

    micro-particles in a “Centrifuge-on-a-chip”. The effects of

    flow condition and particle size on the trapping process were

    investigated. It demonstrates that the derived expression and

    developed model are suitable for the prediction of particles’

    trapping process, which can assist the design of

    “Centrifuge-on-a-chip”.

Publication Date


  • 2013

Citation


  • Zhang, J., Li, M., Li, W. & Alici, G. (2013). Investigation of trapping process in “Centrifuge-on-a-chip”. 2013 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM) (pp. 1266-1271). United States: IEEE.

Scopus Eid


  • 2-s2.0-84883659741

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2271&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/1262

Start Page


  • 1266

End Page


  • 1271

Place Of Publication


  • United States

Abstract


  • “Centrifuge-on-a-chip” is a versatile and

    multifunctional microfluidic chip which can conduct

    operations of selective trapping, enrichment, labeling and

    solution exchange. In this work, the mechanism of selective

    trapping ability was studied by both the experiments and

    numerical simulation. We proved the existence of shear

    gradient lift force in the expansion-contraction cavity and

    derived an explicit expression of it. Also, a numerical

    modeling was developed to study the trapping process of

    micro-particles in a “Centrifuge-on-a-chip”. The effects of

    flow condition and particle size on the trapping process were

    investigated. It demonstrates that the derived expression and

    developed model are suitable for the prediction of particles’

    trapping process, which can assist the design of

    “Centrifuge-on-a-chip”.

Publication Date


  • 2013

Citation


  • Zhang, J., Li, M., Li, W. & Alici, G. (2013). Investigation of trapping process in “Centrifuge-on-a-chip”. 2013 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM) (pp. 1266-1271). United States: IEEE.

Scopus Eid


  • 2-s2.0-84883659741

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2271&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/1262

Start Page


  • 1266

End Page


  • 1271

Place Of Publication


  • United States