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Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B

Journal Article


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Abstract


  • Dear Editor, We read with great interest Leontiev et al.’s paper

    entitled ‘Resveratrol potentiates rapamycin to prevent

    hyperinsulinemia and obesity in male mice on high-fat

    diet’ recently published in Cell Death & Disease.1 Their

    finding that rapamycin and resveratrol have a synergistic

    effect is important for treating insulin resistance. They

    showed that rapamycin inhibited mammalian target of

    rapamycin (mTOR) activity, while resveratrol inhibited S6

    kinase (S6K). We think that these compounds may exert

    their effects through activating protein kinase B (Akt), a key

    regulator of insulin sensitivity. Both the inhibition of mTOR

    by rapamycin and of S6K by resveratrol could result in the

    activation of Akt due to the release of feedback inhibition

    on the insulin receptor substrates (IRS), which are stimulators

    of Akt.

Publication Date


  • 2013

Citation


  • Chen, J. & Huang, X. (2013). Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B. Cell Death and Disease, 4 (June), e680-1-e680-2.

Scopus Eid


  • 2-s2.0-84879664826

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2082&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1064

Has Global Citation Frequency


Start Page


  • e680-1

End Page


  • e680-2

Volume


  • 4

Issue


  • June

Place Of Publication


  • United Kingdom

Abstract


  • Dear Editor, We read with great interest Leontiev et al.’s paper

    entitled ‘Resveratrol potentiates rapamycin to prevent

    hyperinsulinemia and obesity in male mice on high-fat

    diet’ recently published in Cell Death & Disease.1 Their

    finding that rapamycin and resveratrol have a synergistic

    effect is important for treating insulin resistance. They

    showed that rapamycin inhibited mammalian target of

    rapamycin (mTOR) activity, while resveratrol inhibited S6

    kinase (S6K). We think that these compounds may exert

    their effects through activating protein kinase B (Akt), a key

    regulator of insulin sensitivity. Both the inhibition of mTOR

    by rapamycin and of S6K by resveratrol could result in the

    activation of Akt due to the release of feedback inhibition

    on the insulin receptor substrates (IRS), which are stimulators

    of Akt.

Publication Date


  • 2013

Citation


  • Chen, J. & Huang, X. (2013). Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B. Cell Death and Disease, 4 (June), e680-1-e680-2.

Scopus Eid


  • 2-s2.0-84879664826

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2082&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1064

Has Global Citation Frequency


Start Page


  • e680-1

End Page


  • e680-2

Volume


  • 4

Issue


  • June

Place Of Publication


  • United Kingdom