Skip to main content

Chronic effects of cannabis use on the auditory mismatch negativity

Journal Article


Download full-text (Open Access)

Abstract


  • Background

    Cannabis use is associated with the development of psychotic symptoms and increased risk for schizophrenia. The mismatch negativity (MMN) is a brain event-related potential marker of change detection thought to index glutamatergic N-methyl-D-aspartate receptor-mediated neurotransmission, which is known to be deficient in schizophrenia. This study examined auditory MMN in otherwise healthy chronic cannabis users compared with nonuser control subjects.

    Methods

    Forty-two chronic cannabis users and 44 nonuser healthy control subjects completed a multi-feature MMN paradigm, which included duration, frequency, and intensity deviants (deviants 6%; standards 82%). The MMN was compared between users and control subjects as well as between long- and short-term users and age- and gender-matched control subjects. Associations between MMN, cannabis use measures, and symptoms were examined.

    Results

    The MMN amplitude was significantly reduced to frequency but not duration or intensity deviants in overall cannabis users relative to control subjects. Frequency MMN was similarly attenuated in short- and long-term users relative to control subjects. Long-term users also exhibited reduced duration MMN relative to control subjects and short-term users and this was correlated with increased duration of exposure to cannabis and increased psychotic-like experiences during intoxication. In short-term users, a younger age of onset of regular cannabis use and greater frequency of use were associated with greater psychotic-like experiences and symptomatic distress.

    Conclusions

    These results suggest impaired sensory memory that might reflect N-methyl-D-aspartate receptor dysfunction in chronic cannabis users. The pattern of MMN alterations in cannabis users differed from that typically observed in patients with schizophrenia, indicating overlapping but distinct underlying pathology.

Publication Date


  • 2014

Citation


  • Greenwood, L., Broyd, S., Croft, R., Todd, J., Michie, P. T., Johnstone, S., Murray, R. & Solowij, N. (2014). Chronic effects of cannabis use on the auditory mismatch negativity. Biological Psychiatry, 75 (6), 449-458.

Scopus Eid


  • 2-s2.0-84894451421

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1587&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/588

Has Global Citation Frequency


Number Of Pages


  • 9
  • 9

Start Page


  • 449

End Page


  • 458

Volume


  • 75

Issue


  • 6

Place Of Publication


  • United States

Abstract


  • Background

    Cannabis use is associated with the development of psychotic symptoms and increased risk for schizophrenia. The mismatch negativity (MMN) is a brain event-related potential marker of change detection thought to index glutamatergic N-methyl-D-aspartate receptor-mediated neurotransmission, which is known to be deficient in schizophrenia. This study examined auditory MMN in otherwise healthy chronic cannabis users compared with nonuser control subjects.

    Methods

    Forty-two chronic cannabis users and 44 nonuser healthy control subjects completed a multi-feature MMN paradigm, which included duration, frequency, and intensity deviants (deviants 6%; standards 82%). The MMN was compared between users and control subjects as well as between long- and short-term users and age- and gender-matched control subjects. Associations between MMN, cannabis use measures, and symptoms were examined.

    Results

    The MMN amplitude was significantly reduced to frequency but not duration or intensity deviants in overall cannabis users relative to control subjects. Frequency MMN was similarly attenuated in short- and long-term users relative to control subjects. Long-term users also exhibited reduced duration MMN relative to control subjects and short-term users and this was correlated with increased duration of exposure to cannabis and increased psychotic-like experiences during intoxication. In short-term users, a younger age of onset of regular cannabis use and greater frequency of use were associated with greater psychotic-like experiences and symptomatic distress.

    Conclusions

    These results suggest impaired sensory memory that might reflect N-methyl-D-aspartate receptor dysfunction in chronic cannabis users. The pattern of MMN alterations in cannabis users differed from that typically observed in patients with schizophrenia, indicating overlapping but distinct underlying pathology.

Publication Date


  • 2014

Citation


  • Greenwood, L., Broyd, S., Croft, R., Todd, J., Michie, P. T., Johnstone, S., Murray, R. & Solowij, N. (2014). Chronic effects of cannabis use on the auditory mismatch negativity. Biological Psychiatry, 75 (6), 449-458.

Scopus Eid


  • 2-s2.0-84894451421

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1587&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/588

Has Global Citation Frequency


Number Of Pages


  • 9
  • 9

Start Page


  • 449

End Page


  • 458

Volume


  • 75

Issue


  • 6

Place Of Publication


  • United States